Myelin Basic Protein bovine
SIGMA/M1891 - ≥90% (SDS-PAGE), lyophilized powder, suitable for activity assay
Synonym: MBP
MDL Number: MFCD00131640
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: M1891-25MG
| assay | ≥90% (SDS-PAGE) |
| biological source | bovine |
| form | lyophilized powder |
| mol wt | 18.4 kDa |
| Quality Level | 200  |
| solubility | water: 1 mg/mL, clear, colorless to faintly yellow |
| storage condition | (Keep container tightly closed in a dry and well-ventilated place) |
| storage temp. | −20°C |
| technique(s) | activity assay: suitable |
| UniProt accession no. | P02687  |
| Analysis Note: | May contain traces of urea-glycine buffer salts. |
| Application: | Myelin Basic Protein (MBP) bovine has been used: • in in vitro methylation reaction • as a substrate in in vitro immunoprecipitation-kinas • to prepare phosphorylated MBP, which is used as a substrate in phosphatase assays |
| Application: | Used as a kinase substrate. |
| Biochem/physiol Actions: | Mutation of the myelin basic protein gene induces dysmyelination. It is used to induce experimental allergic encephalomyelitis. |
| Biochem/physiol Actions: | Myelin basic protein (MBP) plays a vital role in the formation of the myelin sheath and is associated with various neurological disorders. MBP functions as an antigenic target in the autoimmune disease experimental allergic encephalomyelitis (EAE). MBP plays an essential role in cytoskeletal turnover and membrane extension. Additionally, it is also involved in Fyn-mediated signaling pathways, sequestration of phosphoinositide, and regulation of calcium homoeostasis. MBP functions as an in vitro substrate for mitogen-activated protein kinase (MAP) kinase and aids in the purification and functional studies of enzymes.MBP serves as a potential neuroreceptor. It can stimulate the proliferation of lymphocytes in vitro. MBP plays a key role as a substrate in the mitogen-activated protein (MAP) kinase activation pathway. Based on lymphocyte stimulation, MBP can be used to detect cancer. It is used in several immunological studies. MBP also contributes to the preservation of the lipid: protein organization within myelin. |
| General description: | Research Area: Cell Signaling Myelin basic protein (MBP), a single-chain polypeptide consisting of 170 amino acids with a methyl-arginine, is a peripheral membrane protein. This crucial structural component of the myelin sheath is the second-most abundant protein in myelin representing about 30% of the total myelin protein. |
| Packaging: | 1, 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |