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Moxonidine hydrochloride

SIGMA/M1559 - ≥98%

Synonym: 4-Chloro-6-methoxy-2-methyl-5-(2-imidazolin-2-yl)aminopyrimidine hydrochloride; BDF-5895

CAS Number: 75438-58-3
Empirical Formula (Hill Notation): C9H12ClN5O · HCl
Molecular Weight: 278.14
MDL Number: MFCD06795643
Linear Formula: C9H12ClN5O · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-M1559-10MG 10 mg
 $125.00
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45-M1559-25MG 25 mg
 $249.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: M1559-25MG

 

assay ≥98%
InChI 1S/C9H12ClN5O.ClH/c1-5-13-7(10)6(8(14-5)16-2)15-9-11-3-4-12-9;/h3-4H2,1-2H3,(H2,11,12,15);1H
InChI key ZZPAWQYZQVUVHX-UHFFFAOYSA-N
originator Solvay
Quality Level 100 
SMILES string Cl.COc1nc(C)nc(Cl)c1NC2=NCCN2
Application: Moxonidine hydrochloride has been used:
• as a standard to study its blood-brain barrier (BBB) permeability in porcine brain lipid extract by parallel artificial membrane permeability assay (PAMPA) method
• as a standard to study the chromatographic behavior and lipophilicity by reversed-phase thin-layer chromatography (RP-TLC)
• as an imidazoline I1 receptor agonist to study its effects on excitatory inputs in airway vagal preganglionic neuron (AVPN)
Biochem/physiol Actions: Moxonidine is a selective high-affinity imidazoline I1-receptor agonist and a selectively low-affinity α2-adrenoceptor agonist. It exhibits anti-hypertensive properties by reducing blood pressure efficiently. Moxonidine also exhibits spinal analgesic activity through the α2C-adrenoceptor component.
Features and Benefits: This compound is featured on the Imidazoline Binding Sites  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by Solvay . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 10, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98%
UNSPSC 12352200

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