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4-Methylumbelliferone sodium salt

SIGMA/M1508 - ≥98% (HPLC), crystalline

Synonym: β-Methylumbelliferone; 7-Hydroxy-4-methylcoumarin

CAS Number: 5980-33-6
Empirical Formula (Hill Notation): C10H7NaO3
Molecular Weight: 198.15
EC Number: 227-790-1
MDL Number: MFCD00069856
Linear Formula: C10H7O3Na
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-M1508-10G 10 g
 $137.00
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45-M1508-25G 25 g
 $314.00
1/EA		 Add To Favorites
45-M1508-100G 100 g
 $813.00
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assay ≥98% (HPLC)
color yellow
form crystalline
InChI 1S/C10H8O3.Na/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9;/h2-5,11H,1H3;/q;+1/p-1
InChI key JGMQHDNPUCPRQE-UHFFFAOYSA-M
Quality Level 200 
SMILES string [Na+].CC1=CC(=O)Oc2cc([O-])ccc12
solubility water: 50 mg/mL
Application: 4-Methylumbelliferone sodium salt has been used:
• as a substrate to analyze the enzyme kinetics of its glucuronidation in the human liver
• as a standard to quantify the free 4-methylumbelliferone released as a result of enzyme-substrate action
• in cell survival assay to inhibit hyaluronan (HA) production and to study its effect on chemoresistance in ovarian cancer
Biochem/physiol Actions: 4-methylumbelliferone (4-MU) serves as a hyaluronan (HA) synthesis blocker. It exhibits anti-inflammatory, anti-fibrogenic, and antitumor properties. 4-MU is used to treat biliary spasms and might also be beneficial in nonalcoholic steatohepatitis (NASH), inflammation, hepatocyte injury, and fibrotic response. 4-MU is known to be glucuronidated by most of the uridine 5ฺ-diphospho-glucuronosyltransferase (UGT) isoforms of the human liver. This makes it a potent probe substrate to examine the overall hepatic UGTs activity.
General description: 4-methylumbelliferone (4-MU) is a coumarin derivative.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
UNSPSC 12352204

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