1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride

SIGMA/M0896 - powder

Synonym: MPTP HCl; Pyridine, 1,2,3,6-tetrahydro-1-methyl-4-phenyl-, hydrochloride; MPTP hydrochloride

CAS Number: 23007-85-4
Empirical Formula (Hill Notation): C₁₂H₁₅N · HCl
Molecular Weight: 209.72
MDL Number: MFCD00012790
Linear Formula: C₁₂H₁₅N · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-M0896-10MG	10 mg	$0.00 1/EA CALL FOR PRICE	Add To Favorites
45-M0896-100MG	100 mg	$434.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

color	white to off-white
drug control	kontrollierte Droge in Deutschland
form	powder
InChI	1S/C12H15N.ClH/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-7H,8-10H2,1H3;1H
InChI key	KOWJANGMTAZWDT-UHFFFAOYSA-N
Quality Level	200
SMILES string	Cl[H].CN1CCC(=CC1)c2ccccc2

Application:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride has been used to induce Parkinson′s disease (PD) in animal models: • to study the effect of docosahexaenoic acid on the apelin distribution of the nervous system • to study the behavioral impairments correlated to neurochemical deficits • to study the effects of treadmill exercise on neuroprotection and neuroinflammation
Application:	MPTP has been used to study its effects on microglial innate immune memory. It has also been used to study the protective effects of phenylpropionamides in Pakinson’s diseased mice models.
Biochem/physiol Actions:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a piperidine derivative and dopaminergic neurotoxin, useful in neurological research. MPTP is metabolized to 1-methyl-4-phenylpyridine (MPP+), which in turn can cause free radical production in vivo and lead to oxidative stress. Thus MPP+ is generally acknowledged as the active metabolite of MPTP. MPTP is widely used in in vivo research studies as a model for Parkinsonism. A review describes the application of MPTP in studies related to programmed cell death in neurogenerative diseases.
Biochem/physiol Actions:	Dopaminergic neurotoxin.
Disclaimer:	Reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.
General description:	MPTP shows its effects by causing inflammation, excitotoxicity, mitochondrial apoptosis, formation of inclusion bodies, and oxidative stress that leads to dopaminergic neuronal damage in the striatum and substantia nigra. In dopaminergic neurons, MPTP blocks the mitochondrial complex I which leads to mitochondrial dysfunction.
Legal Information:	German Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG. English This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.
Other Notes:	2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research
Packaging:	10, 100 mg in serum bottle

Symbol	GHS06,GHS08
Signal word	Danger
Hazard statements	H301 - H370
Precautionary statements	P260 - P264 - P270 - P301 + P310 - P405 - P501
Hazard Codes	T
Risk Statements	25-36/37/38-39/23/24/25
Safety Statements	26-39-45
RIDADR	UN 2811 6.1 / PGII
WGK Germany	WGK 3

UNSPSC

12352200

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