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Mdivi-1

SIGMA/M0199 - ≥98% (HPLC), powder

Synonym: 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone; 3-(2,4-Dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone

CAS Number: 338967-87-6
Empirical Formula (Hill Notation): C15H10Cl2N2O2S
Molecular Weight: 353.22
MDL Number: MFCD00974506
Linear Formula: C15H10Cl2N2O2S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-M0199-5MG 5 mg
 $71.60
1/EA		 Add To Favorites
45-M0199-25MG 25 mg
 $285.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C15H10Cl2N2O2S/c1-21-13-7-12(9(16)6-10(13)17)19-14(20)8-4-2-3-5-11(8)18-15(19)22/h2-7H,1H3,(H,18,22)
InChI key NZJKEVWTYMOYOR-UHFFFAOYSA-N
Quality Level 100 
shipped in wet ice
SMILES string COc1cc(N2C(S)=Nc3ccccc3C2=O)c(Cl)cc1Cl
solubility DMSO: >20 mg/mL
storage temp. −20°C
Application: Mdivi-1 has been used:
• in embryonic thoracic aorta A7r5 cells to inhibit cell migration and proliferation
• in mitochondrial network reshaping and reactive oxygen species (ROS) production studies in oligodendrocyte precursor cells (OPCs)
• to induce mitochondrial damage in lung fibroblasts
Biochem/physiol Actions: Mdivi-1 is a cell-permeable selective inhibitor of mitochondrial division DRP (dynamin-related GTPase) and inhibitor of the mitochondrial division dynamin (Dnm1). Mitochondrial fusion and division play important roles in the regulation of apoptosis. Mdivi-1 is the first selective inhibitor of mitochondrial division dynamins. In principle, Mdivi-1 represents a class of therapeutics for stroke, myocardial infarction, and neurodegenerative diseases.
Biochem/physiol Actions: Mdivi-1 is a selective inhibitor of mitochondrial division DRP (dynamin-related GTPase); inhibitor of the mitochondrial division dynamin (Dnm1).
Features and Benefits: This compound is a featured product for Apoptosis research. Click here  to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
General description: Mitochondrial Division Inhibitor 1 (Mdivi-1) is a quinazolinone derivative and is cell permeable. It traverses blood-brain barrier and elicits protective functionality in heart and brain ischemia-reperfusion injury.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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