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LY-294,002 hydrochloride

SIGMA/L9908 - solid, ≥98% (HPLC)

Synonym: 2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride

CAS Number: 934389-88-5
Empirical Formula (Hill Notation): C19H17NO3 · HCl
Molecular Weight: 343.80
MDL Number: MFCD00270881
Linear Formula: C19H17NO3 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-L9908-1MG 1 mg
 $76.20
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45-L9908-5MG 5 mg
 $196.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: L9908-1MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: L9908-5MG

 

assay ≥98% (HPLC)
biological source microbial (Staphylococcus roseus)
color white to off-white
form solid
InChI 1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
InChI key CZQHHVNHHHRRDU-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C1C=C(Oc2c1cccc2-c3ccccc3)N4CCOCC4
solubility DMSO: >5 mg/mL
  H2O: insoluble
storage temp. 2-8°C
Application: LY-294,002 hydrochloride has been used in the inhibition of:
• phosphoinositide 3-kinase (PI3K) in human lung cancer cell line
• autophagy in mesenchymal stem cells (MSCs).
• serine/threonine-specific protein kinase (AKT) signaling in fibroblasts and cardiac cells.
Biochem/physiol Actions: Specific cell permeable phosphatidylinositol 3-kinase inhibitor.
Features and Benefits: This compound is a featured product for Cyclic Nucleotide and Kinase Phosphatase Biology research. Discover more featured Cyclic Nucleotide  and Kinase Phosphatase Biology  products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the G Proteins (Heterotrimeric)  and Phosphoinositide Kinases  pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description: LY-294,002 hydrochloride is a derivative of the flavonoid, quercetin and elicits higher inhibition on the enzyme phosphoinositide 3-kinase (PI3K). LY-294,002 inhibits nuclear factor kappa B signaling in macrophages. It elevates expression of autophagosomal protein LC3 and promotes apoptosis in gastric and nasopharyngeal cancer cells. LY-294,002 modulates action potential repolarization and improves myocyte contractility.
Packaging: 1, 5 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352207

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