L-Leucine

SIGMA/L8000 - reagent grade, ≥98% (HPLC)

Synonym: (S)-2-Amino-4-methylpentanoic acid

CAS Number: 61-90-5
Empirical Formula (Hill Notation): C₆H₁₃NO₂
Molecular Weight: 131.17
EC Number: 200-522-0
MDL Number: MFCD00002617
Linear Formula: (CH₃)₂CHCH₂CH(NH₂)CO₂H
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-L8000-25G	25 g	$38.70 1/EA	Add To Favorites
45-L8000-50G	50 g	$72.90 1/EA	Add To Favorites
45-L8000-100G	100 g	$114.00 1/EA	Add To Favorites
45-L8000-250G	250 g	$251.00 1/EA	Add To Favorites
45-L8000-1KG	1 kg	$767.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: L8000-25G

Properties
Descriptions
Safety Info.
Basic Data

application(s)	peptide synthesis
assay	≥98% (HPLC)
color	white to off-white
form	powder
grade	reagent grade
impurities	isoleucine and methionine, essentially free
InChI	1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1
InChI key	ROHFNLRQFUQHCH-YFKPBYRVSA-N
mp	>300 °C (lit.)
Quality Level	200
SMILES string	CC(C)C[C@H](N)C(O)=O
technique(s)	ligand binding assay: suitable

Application:	L-Leucine has been used as an agonist of mechanistic target of rapamycin (mTOR) to determine whether AMPK/mTOR pathway is involved in berberine-mediated autophagy in J774A.1 cells. It has also been used for the selection of transformed cells.
Biochem/physiol Actions:	Leucine is a non-glucogenic, essential amino acid. It is a branched-chain amino acid that is a structural component of proteins. Leucine positively influences insulin release to eliminate toxic sugars out of the blood. The degradation of leucine leads to the formation of ketone bodies.
Packaging:	1 kg in poly bottle
Packaging:	25, 50, 100, 250 g in poly bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 1
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
mp	>300 °C (lit.)
UNSPSC	12352209

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