Levocetirizine dihydrochloride

SIGMA/L7795 - ≥98% (HPLC)

Synonym: Levocetirizine dihydrochloride; (-)-Cetirizine dihydrochloride; 2-[2-[4-[(R)-(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid dihydrochloride

CAS Number: 130018-87-0
Empirical Formula (Hill Notation): C₂₁H₂₅ClN₂O₃·2HCl
Molecular Weight: 461.81
MDL Number: MFCD07366507
Linear Formula: C₂₁H₂₅ClN₂O₃·2HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-L7795-10MG	10 mg	$107.00 1/EA	Add To Favorites
45-L7795-50MG	50 mg	$415.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
form	powder
InChI	1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H/t21-;;/m1../s1
InChI key	PGLIUCLTXOYQMV-GHVWMZMZSA-N
Quality Level	100
SMILES string	Cl.Cl.OC(=O)COCCN1CCN(CC1)[C@H](c2ccccc2)c3ccc(Cl)cc3
solubility	H₂O: ≥23 mg/mL
storage condition	desiccated
storage temp.	room temp

Application:	Levocetirizine dihydrochloride has been used as standard in the thin layer chromatography optimization and in preparation of racemic cetirizine standard for subcritical fluid chromatography-tandem mass spectrometry analysis.
Biochem/physiol Actions:	Levocetirizine dihydrochloride is a nonsedating type histamine H1-receptor antagonist; active isomer of cetirizine
Biochem/physiol Actions:	Levocetirizine hydrochloride is a nonsedating antihistamine. It is a histamine H1-receptor antagonist, the active isomer of cetirizine. Levocetirizine has high bioavailability, high affinity for and occupancy of the H1 receptor.
Features and Benefits:	This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description:	Levocetirizine dihydrochloride is the R-enantiomer of cetirizine and is used for treating seasonal allergic rhinitis and chronic idiopathic urticaria. The liver metabolizes 14% of levocetirizine and rest is excreted in urine. The response of levocetirizine to histamine is comparatively higher to cetirizine.
Packaging:	10, 50 mg in glass bottle

Symbol	GHS07,GHS09
Signal word	Warning
Hazard statements	H302 - H400
Precautionary statements	P273 - P301 + P312 + P330
Hazard Codes	Xn,N
Risk Statements	22-50/53
Safety Statements	60-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	room temp
UNSPSC	12352200

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