Synonym: (-)-OR-1259; (R)-Simendan; 2-[2-[4-[(4R)-1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]hydrazinylidene]-propanedinitrile; OR 1259; R)-((4-(1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl)hydrazono) propanedintrile
CAS Number: 141505-33-1
Empirical Formula (Hill Notation): C14H12N6O
Molecular Weight: 280.28
MDL Number: MFCD00867135
Linear Formula: C14H12N6O
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
yellow |
| form |
powder |
| InChI |
1S/C14H12N6O/c1-9-6-13(21)19-20-14(9)10-2-4-11(5-3-10)17-18-12(7-15)8-16/h2-5,9,17H,6H2,1H3,(H,19,21)/t9-/m1/s1 |
| InChI key |
WHXMKTBCFHIYNQ-SECBINFHSA-N |
| optical activity |
[α]/D -500 to -650°, c = 0.5 in THF |
| Quality Level |
100  |
| SMILES string |
C[C@@H]1CC(=O)NN=C1c2ccc(NN=C(C#N)C#N)cc2 |
| solubility |
DMSO: ≥20 mg/mL |
| storage temp. |
room temp |
| Application: |
Levosimendan has been used for screening its anti-human immunodeficiency virus type 1 (HIV-1) property. It has also been used for screening its cytotoxic effects in TP53 mutant and wild-type lung adenocarcinoma cell lines |
| Biochem/physiol Actions: |
Levosimendan has a potential to inhibit both acute human immunodeficiency virus type 1 (HIV-1) replication and the reactivation of latent HIV-1 proviruses. Therefore, it is considered to be a promising anti-HIV-1 agent. |
| Biochem/physiol Actions: |
Levosimendan is a calcium sensitiser. |
| Biochem/physiol Actions: |
Levosimendan is a calcium sensitiser. The compound increases the sensitivity of the heart to calcium, thus increasing cardiac contractility without a rise in intracellular calcium. Levosimendan binds to cardiac troponin C in a calcium-dependent manner and stabilizes troponin C. This is followed by actin-myosin cross-bridges, without increasing myocardial consumption of ATP. Additionally the compound acts as vasodilator by opening an ATP-sensitive potassium channels. Levosimendan is a drug used for treatment of congestive heart failure. Also it can be used to treat calcium channel blocker overdose. |
| Packaging: |
10, 50 mg in glass bottle |
| Symbol |
 GHS07 |
| Signal word |
Warning |
| Hazard statements |
H302 - H312 - H332 |
| Precautionary statements |
P280 |
| Hazard Codes |
Xn |
| Risk Statements |
20/21/22 |
| Safety Statements |
36/37 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
room temp |
| UNSPSC |
12352202 |
