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Leptomycin B solution from Streptomyces sp.

SIGMA/L2913 - ≥95% (HPLC), Supplied in methanol: water (7:3)

Synonym: Antibiotic CI 940; Elactocin; LMB; Mantuamycin

CAS Number: 87081-35-4
Empirical Formula (Hill Notation): C33H48O6
Molecular Weight: 540.73
MDL Number: MFCD06795848
Linear Formula: C33H48O6
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-L2913-.5UG 0.5 µg
 $59.30
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45-L2913-2X.5UG 0.5 µg
 $110.00
2/EA		 Add To Favorites
45-L2913-5X.5UG 0.5 µg
 $241.00
5/EA		 Add To Favorites
45-L2913-10X.5UG 0.5 µg
 $377.00
10/EA		 Add To Favorites
45-L2913-5UG 5 µg
 $410.00
1/EA		 Add To Favorites

 

antibiotic activity spectrum fungi
assay ≥95% (HPLC)
InChI 1S/C33H48O6/c1-9-28(14-15-29-24(5)13-16-31(36)39-29)19-22(3)12-10-11-21(2)17-25(6)32(37)27(8)33(38)26(7)18-23(4)20-30(34)35/h10-11,13-17,19-20,22,24-27,29,33,38H,9,12,18H2,1-8H3,(H,34,35)/b11-10+,15-14+,21-17+,23-20+,28-19-/t22-,24+,25-,26+,27-,29+,33-/m1/s1
InChI key YACHGFWEQXFSBS-XYERBDPFSA-N
mode of action protein synthesis | interferes
Quality Level 300 
shipped in dry ice
SMILES string CCC(C=C[C@@H]1OC(=O)C=C[C@@H]1C)=C[C@H](C)CC=CC(C)=C[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)CC(C)=CC(O)=O
storage condition protect from light
storage temp. −20°C
Biochem/physiol Actions: Leptomycin B is an unsaturated, branched-chain fatty acid, and is an important tool in the study of nuclear export. Leptomycin B is a specific inhibitor of proteins containing nuclear export signal. Leptomycin B inhibits nucleo-cytoplasmic translocation of molecules such as the HIV-1 Rev protein and Rev-dependent export of mRNA. The addition of very small amounts to fibroblasts causes accumulation of MEK in the nucleus. Other proteins that are influenced by leptomycin B are actin, c-Abl, cyclin B1, MDM2/p53, IκB, MPF, and PKA. The suggested inhibition mechanism involves the direct binding of leptomycin B to CRM1, which blocks the binding of CRM1 to proteins containing the nuclear export signal, via the interaction with cysteine residue in CRM1 control conserved region.
General description: Leptomycin B is an anti-fungal antibiotic, anti-tumor cytotoxin that inhibits CRM1-dependent, NES-dependent nucleo-cytoplasmic translocation (nuclear export inhibitor). NES containing proteins include HIV-1 REV; actin, c-Abl, cyclin B1, MDM2/p53, I?B, MPF, PKA and MEK.
Purity ≥95% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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