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L-Leucine-7-amido-4-methylcoumarin hydrochloride

SIGMA/L2145

Synonym: H-L-Leu-AMC HCl

CAS Number: 62480-44-8
Empirical Formula (Hill Notation): C16H20N2O3 · HCl
Molecular Weight: 324.80
MDL Number: MFCD00043262
Linear Formula: C16H20N2O3 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-L2145-5MG 5 mg
 $114.00
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45-L2145-25MG 25 mg
 $373.00
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45-L2145-100MG 100 mg
 $1120.00
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assay ≥98% (TLC)
fluorescence λex 327 nm; λem 349 nm (pH 8.0)
  λex 380 nm; λem 440 nm (Reaction product)
form powder
InChI 1S/C16H20N2O3.ClH/c1-9(2)6-13(17)16(20)18-11-4-5-12-10(3)7-15(19)21-14(12)8-11;/h4-5,7-9,13H,6,17H2,1-3H3,(H,18,20);1H/t13-;/m0./s1
InChI key VCRXITKKWBOQRZ-ZOWNYOTGSA-N
Quality Level 200 
SMILES string Cl.CC(C)C[C@H](N)C(=O)Nc1ccc2C(C)=CC(=O)Oc2c1
solubility methanol: 50 mg/mL, clear, colorless to faintly yellow
storage temp. −20°C
Application: L-Leucine-7-amido-4-methylcoumarin hydrochloride (Leu-AMC) as a substrate analog to determine leucine aminopeptidase activity
Application: L-Leucine-7-amido-4-methylcoumarin hydrochloride has been used:• as a substrate in fluorescence-based soil assays
• to determine leucine aminopeptidase activity of both Plasmodium falciparum M1 (PfA-M1) and PfA-M17 enzymes
General description: L-Leucine-7-amido-4-methylcoumarin hydrochloride (Leu-AMC) is a fluorogenic peptidyl substrate for leucine aminopeptidase, an extracellular enzyme found abundantly in natural aquatic systems. This enzyme is one of the various enzymes used by bacteria for protein hydrolysis.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (TLC)
Storage Temp. −20°C
UNSPSC 12352204

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