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LY-487379 hydrochloride

SIGMA/L1170 - ≥98% (HPLC)

Synonym: N-(4-(2-Methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine hydrochloride

CAS Number: 353229-59-1
Empirical Formula (Hill Notation): C21H19F3N2O4SHCl
Molecular Weight: 488.91
MDL Number: MFCD11519970
Linear Formula: C21H19F3N2O4SHCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-L1170-25MG 25 mg
 $0.00
1/EA
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assay ≥98% (HPLC)
color off-white
form powder
InChI 1S/C21H19F3N2O4S.ClH/c1-29-19-6-2-3-7-20(19)30-18-10-8-17(9-11-18)26(14-16-5-4-12-25-13-16)31(27,28)15-21(22,23)24;/h2-13H,14-15H2,1H3;1H
InChI key LPWFRDWTOKLHJC-UHFFFAOYSA-N
originator Eli Lilly
Quality Level 100 
SMILES string Cl.COc1ccccc1Oc2ccc(cc2)N(Cc3cccnc3)S(=O)(=O)CC(F)(F)F
solubility DMSO: >20 mg/mL
storage condition desiccated
storage temp. 2-8°C
Biochem/physiol Actions: LY-487379 is a positive allosteric modulator of the metabotropic glutamate receptor mGluR2.
Biochem/physiol Actions: LY-487379 is a positive allosteric modulator of the metabotropic glutamate receptor mGluR2. EC50 = 1.7 μM. LY-487379 shows no intrinsic agonist or antagonist activity at hmGluR2 and has no activity at human mGluR3. LY-487379 markedly potentiates glutamate-stimulated [35S]GTPγS binding in a concentration-dependent manner at hmGluR2, shifting the glutamate dose-response curve leftward by 3-fold and increasing the maximum levels of [35S]GTPγS stimulation. LY-487379 has anxiolytic effects in fear-potentiated startle. This activity profile is useful in all symptom domains of schizophrenia.
Features and Benefits: This compound is featured on the Glutamate Receptors (G Protein Family)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by Eli Lilly . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany 3
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352209

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