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Latanoprost

SIGMA/L1167 - ≥98% (HPLC)

Synonym: Isopropyl (5Z,9α,11α,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oate; Isopropyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate; Xalatan

CAS Number: 130209-82-4
Empirical Formula (Hill Notation): C26H40O5
Molecular Weight: 432.59
MDL Number: MFCD00216074
Linear Formula: C26H40O5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-L1167-1MG 1 mg
 $181.00
1/EA		 Add To Favorites
45-L1167-5MG 5 mg
 $628.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color colorless to yellow
form oil
InChI 1S/C26H40O5/c1-19(2)31-26(30)13-9-4-3-8-12-22-23(25(29)18-24(22)28)17-16-21(27)15-14-20-10-6-5-7-11-20/h3,5-8,10-11,19,21-25,27-29H,4,9,12-18H2,1-2H3/b8-3-/t21-,22+,23+,24-,25+/m0/s1
InChI key GGXICVAJURFBLW-CEYXHVGTSA-N
originator Johnson & Johnson
Quality Level 100 
shipped in wet ice
SMILES string CC(C)OC(=O)CCCC=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc2ccccc2
solubility DMSO: freely soluble
  methanol: soluble
storage temp. −20°C
Application: Latanoprost has been used:
• in the preparation of thermo-sensitive hydrogel consisting of curcumin-loaded nanoparticles (CUR-NPs) to determine its therapeutic effects on human trabecular meshwork (TM) cells under oxidative stress.
• as an ester pro-drug to study its effects on the murine ocular surface in mice.
• in the preparation of thermo-sensitive hydrogel to study its effects on controlling ocular hypertension.
Biochem/physiol Actions: Latanoprost is a potent, selective prostaglandin F2α analog receptor agonist. It is hydrolyzed by esterases into its biologically active form latanoprost acid in the cornea. Latanoprostplays a role in reducing the intraocular pressure (IOP) due to which it has therapeutic effects in treating glaucoma.
Features and Benefits: This compound is featured on the Prostanoid Receptors  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by Johnson & Johnson . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 1, 5 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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