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Leupeptin hydrochloride

SIGMA/L0649 - microbial, ≥70% (HPLC)

Synonym: Acetyl-Leu-Leu-Arg-al hydrochloride

CAS Number: 24125-16-4
Empirical Formula (Hill Notation): C20H38N6O4 · HCl
Molecular Weight: 463.01
MDL Number: MFCD00133457
Linear Formula: C20H38N6O4 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-L0649-5MG 5 mg
 $96.20
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45-L0649-25MG 25 mg
 $337.00
1/EA		 Add To Favorites
45-L0649-100MG 100 mg
 $1110.00
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assay ≥70% (HPLC)
biological source microbial
form powder
InChI 1S/C20H38N6O4.ClH/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);1H
InChI key OQQYPQNFLLAILR-UHFFFAOYSA-N
Quality Level 200 
SMILES string Cl.CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C=O
solubility water: 50 mg/mL, clear, colorless to yellow
storage temp. −20°C
Analysis Note: Leupeptin gives multiple peaks on HPLC because of the formation of tautomeric isomers in solution. Majority of contaminating peptide is racemized leupeptin.
Biochem/physiol Actions: Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM.
Biochem/physiol Actions: Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)
Packaging: 5, 25, 100 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥70% (HPLC)
Storage Temp. −20°C
UNSPSC 12352202

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