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Kasugamycin hydrochloride from Streptomyces kasugaensis

SIGMA/K4013

Synonym: 3-O-[2-Amino-4-[(carboxyiminomethyl)amino]-2,3,4,6-tetradeoxy-D-arabino-hexopyranosyl]-D-chiro-inositol

CAS Number: 19408-46-9
Empirical Formula (Hill Notation): C14H25N3O9 · HCl
Molecular Weight: 415.82
MDL Number: MFCD00058459
Linear Formula: C14H25N3O9 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-K4013-10G 10 g
 $442.00
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antibiotic activity spectrum Gram-negative bacteria
  Gram-positive bacteria
biological source Streptomyces kasugaensis
color white to off-white
form powder
InChI 1S/C14H25N3O9.ClH/c1-3-5(17-12(16)13(23)24)2-4(15)14(25-3)26-11-9(21)7(19)6(18)8(20)10(11)22;/h3-11,14,18-22H,2,15H2,1H3,(H2,16,17)(H,23,24);1H/t3-,4+,5+,6-,7+,8+,9-,10+,11+,14-;/m1./s1
InChI key ZDRBJJNXJOSCLR-NZXABURVSA-N
mode of action protein synthesis | interferes
Quality Level 200 
SMILES string C[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H]2O)[C@@H](N)C[C@@H]1NC(C(O)=O)=N.Cl
storage temp. 2-8°C
Application: Kasugamycin (Ksg) is an aminoglycoside antibiotic isolated from Streptomyces kasugaensis. It is used to study ribosome structure and interactions near the m26A m26A sequence. It is used to study the mechanisms of kasugamycin resistance.
Biochem/physiol Actions: Kasugamycin binds within the mRNA channel of the 30S subunit between the universally conserved G926 and A794 nucleotides in 16S ribosomal RNA. It inhibits protein synthesis and binding of aminoacyl-sRNA to the ribosomes in fungi and induces f-met-tRNA dissociation from the P-site of the 30S subunit.
General description: Chemical structure: aminoglycoside
Packaging: 10 g in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 2
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Storage Temp. 2-8°C
UNSPSC 51102829

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