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L-Kynurenine sulfate salt

SIGMA/K3750 - crystalline

Synonym: β-Anthraniloyl-L-alanine; L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid

CAS Number: 16055-80-4
Empirical Formula (Hill Notation): C10H12N2O3 · H2O4S
Molecular Weight: 306.29
MDL Number: MFCD00039104
Linear Formula: C10H12N2O3 · H2SO4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-K3750-500MG 500 mg
 $0.00
1/EA
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45-K3750-1G 1 g
 $0.00
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45-K3750-5G 5 g
 $2010.00
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assay ≥98% (HPLC)
color light yellow
form crystalline
InChI 1S/C10H12N2O3.H2O4S/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15;1-5(2,3)4/h1-4,8H,5,11-12H2,(H,14,15);(H2,1,2,3,4)/t8-;/m0./s1
InChI key KAXRWMOLNJZCEW-QRPNPIFTSA-N
Quality Level 200 
SMILES string OS(O)(=O)=O.N[C@@H](CC(=O)c1ccccc1N)C(O)=O
storage temp. −20°C
technique(s) ligand binding assay: suitable
Application: L-Kynurenine sulfate salt has been used as a substrate to study the enzyme activity of kynurenine aminotransferase. It has also been used in the synthesis of Kyn adducts of certain amino acids .
Biochem/physiol Actions: Key intermediate in the breakdown pathway of tryptophan.
Biochem/physiol Actions: L-Kynurenine (L-Kyn) is a precursor of kynurenic acid which is the only recognized endogenous excitatory amino acid receptor antagonist in the central nervous system. L-Kyn is known to be a pigment generating component in animals. In mammals, it modulates the transmission of glutamate neurotransmitter. It is also considered to be a sex-attracting pheromone in vertebrates.
Biochem/physiol Actions: L-Kynurenine is a key intermediate in the breakdown of L-tryptophan and the formation of nicotinamide adenine dinucleotide (NAD+) via the kynurenine pathway. L-kynurenine is involved in a variety of neurological processes and diseases. L-kynurenine is a substrate for kynureninase/kynurenine hydrolase; kynurenine 3-monooxygenase and kynurenine-oxoglutarate transaminase.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352209

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