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KH7

SIGMA/K3394 - ≥98% (HPLC)

Synonym: (E)-2-(1H-Benzo[d]imidazol-2-ylthio)-N′-(5-bromo-2-hydroxybenzylidene)propanehydrazide

CAS Number: 330676-02-3
Empirical Formula (Hill Notation): C17H15BrN4O2S
Molecular Weight: 419.30
MDL Number: MFCD01230899
Linear Formula: C17H15BrN4O2S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-K3394-5MG 5 mg
 $289.00
1/EA		 Add To Favorites
45-K3394-25MG 25 mg
 $1090.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
form powder
InChI 1S/C17H15BrN4O2S/c1-10(25-17-20-13-4-2-3-5-14(13)21-17)16(24)22-19-9-11-8-12(18)6-7-15(11)23/h2-10,23H,1H3,(H,20,21)(H,22,24)/b19-9+
InChI key WILMXUAKQKGGCC-DJKKODMXSA-N
Quality Level 100 
SMILES string CC(Sc1nc2ccccc2[nH]1)C(=O)NN=Cc3cc(Br)ccc3O
solubility DMSO: >20 mg/mL
storage temp. 2-8°C
Application: KH7 has been used:
• as a soluble adenyl cyclase (sAC) antagonist to study its effect on the signaling pathway mediated by the action of transient  receptor type 1 (TRPV1) in sperm cells.
• as a selective sAC antagonist to study its effect on the signaling pathway of proton gated channels (HV1) induced action in sperm cells.
• as a sAC inhibitor to study its effects on cAMP increase in monophosphorylated myosin light chain (pMLC).
Application: KH7 is not active against sAC in the presence of detergents. When used in cellular experiments, KH7 exhibits non-specific membrane disruption effects at concentrations above 50 μM.
Biochem/physiol Actions: KH7 is a selective inhibitor of soluble adenylyl cyclase.
Biochem/physiol Actions: KH7 is a selective inhibitor of soluble adenylyl cyclase. Soluble adenylyl cyclase (sAC) is an ubiquitously expressed, essential component of cAMP-signaling.
Features and Benefits: This compound is a featured product for Cyclic Nucleotide research. Click here  to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the Adenylyl cyclases  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Symbol GHS06  GHS06
Signal word Danger
Hazard statements H301
Precautionary statements P301 + P310
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR UN 2811 6.1 / PGIII
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 41106305

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