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Kynurenic acid

SIGMA/K3375 - ≥98%

Synonym: 4-Hydroxyquinoline-2-carboxylic acid

CAS Number: 492-27-3
Empirical Formula (Hill Notation): C10H7NO3
Molecular Weight: 189.17
EC Number: 207-751-5
MDL Number: MFCD00006753
Linear Formula: C10H7NO3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-K3375-250MG 250 mg
 $21.20
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45-K3375-1G 1 g
 $48.40
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45-K3375-5G 5 g
 $168.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: K3375-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: K3375-250MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: K3375-5G

 

assay ≥98%
form powder
InChI 1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)
InChI key HCZHHEIFKROPDY-UHFFFAOYSA-N
mp 275 °C (dec.) (lit.)
Quality Level 200 
SMILES string OC(=O)c1cc(O)c2ccccc2n1
Application: Kynurenic acid has been used as a constituent in dissection saline solution for embryonic cerebral cortical cells and human primary astrocytes. It has also been used as a medium supplement for murine intestinal epithelial cell line, MODE-K and induced pluripotent stem cell (iPSC)-derived neurons cells.
Biochem/physiol Actions: Kynurenic acid (KynA) is a non-selective antagonist of N-methyl-d-aspartate (NMDA), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate receptors. It blocks kainic acid neurotoxicity. Kynurenic acid also blocks nicotinic acetylcholine receptors. It is a by-product of tryptophan catabolic pathway. Kynurenic acid is a neuromodulator and controls the levels of glutamate, dopamine, acetylcholine and α-aminobutyric acid (GABA). KynA controls neuroendocrine functions and altered levels of KynA is a potential marker in depression, schizophrenia Alzheimer′s and Huntington′s diseases. Normal levels of KynA in the brain is crucial for the cognitive function.
Features and Benefits: This compound is a featured product for Neuroscience research. Click here  to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 1, 5 g in poly bottle
Packaging: 250 mg in poly bottle
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98%
mp 275 °C (dec.) (lit.)
UNSPSC 12352106

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