Kallikrein from human plasma
SIGMA/K2638 - buffered aqueous solution, ≥5 units/mg protein
Synonym: Kininogenase; Kininogenin
CAS Number: 9001-01-8
MDL Number: MFCD00131428
Product Type: Chemical
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| form | buffered aqueous solution |
| Quality Level | 100  |
| shipped in | dry ice |
| specific activity | ≥5 units/mg protein |
| storage temp. | −20°C |
| UniProt accession no. | P06870  |
| Application: | Kallikrein from human plasma has been used: • to culture human hepatocellular carcinoma cell line • to study its effects on the cleavage of Neisserial heparin binding antigen (NHBA) from Neisseria meningitidis • in peptidase inhibition assay |
| Biochem/physiol Actions: | Plasma kallikrein (PK) is involved in the synthesis of bradykinin, maintaining the blood metabolite levels and hypertension. It also participates in the activation of coagulation factor XII, which promotes inflammation and the intrinsic coagulation pathway. PK controls proteolytic cascades in the cardiovascular system like the kallikrein-kinin system, renin-angiotensin system, fibrinolytic system, and the alternative complement pathway. It is involved in the cleavage of glucagon-like peptide-1 (GLP-1) and neuropeptide Y (NPY) which suggests that plasma kallikrein may affect metabolism and diabetes. |
| General description: | Kallikrein-related peptidases belong to the family of 15 highly conserved trypsin- or chymotrypsin-like serine proteases. Plasma kallikrein (PK) is a serine protease derived from plasma prekallikrein, a zymogen found at higher levels in blood circulation. The KLKB1 gene is located on the human chromosome at 4q35.2. |
| Other Notes: | One unit will hydrolyze 1.0 μmole of Nα-benzoyl- |
| Physical form: | Solution in 20 mM Tris-HCl, pH 7.8 with 100 mM NaCl. |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| activity | specific activity: ≥5 units/mg protein |
| Storage Temp. | −20°C |
| Enzyme Commission (EC) Number | 3.4.21.34 ( BRENDA | IUBMB ) |
| UNSPSC | 12352204 |