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Kainic acid monohydrate

SIGMA/K2389 - ≥98% (HPLC), from Digenea simplex

Synonym: 2-Carboxy-3-carboxymethyl-4-isopropenylpyrrolidine

CAS Number: 58002-62-3
Empirical Formula (Hill Notation): C10H15NO4 · H2O
Molecular Weight: 231.25
MDL Number: MFCD00150833
Linear Formula: C10H15NO4 · H2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-K2389-10MG 10 mg
 $355.00
1/EA		 Add To Favorites
45-K2389-50MG 50 mg
 $1290.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
biological source Digenea simplex
color white
form powder
InChI 1S/C10H15NO4.H2O/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13;/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15);1H2/t6-,7+,9-;/m0./s1
InChI key FZNZRJRSYLQHLT-SLGZUKMRSA-N
Quality Level 100 
SMILES string O.CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
solubility H2O: >10 mg/mL
storage temp. 2-8°C
Application: Kainic acid monohydrate has been used:
• As a convulsant to induce epileptogenesis and epilepsy in mice.
• To stimulate in vitro excitotoxic trauma in spiral ganglion neurons on inner hair cells.
• To induce seizures in rat model.
• To induce status epilepticus in adult male Wistar rats.
Biochem/physiol Actions: Agonist for kainate class of ionotropic glutamate receptors.
Biochem/physiol Actions: Ionotropic glutamate receptors form ion channels, and conduct Na+ and K+ fluxes. The receptors possess an agonist binding site and it encounters a conformational change upon agonist binding to it. Kainate gated channels participate in glutamate-induced excitatory postsynaptic neuronal potential.
Biochem/physiol Actions: Kainic acid monohydrate is an agonist at the kainate class of ionotropic glutamate receptors, which induces seizures and neurodegeneration in vivo and is used to induce experimental epilepsy in rodents and study the mechanisms of excitation-induced neuronal apoptosis.
Packaging: 10, 50 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352106

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