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K-252a

SIGMA/K2015 - Ready Made Solution, from Nonomuraea longicatena, >98%

Synonym: SF 2370

CAS Number: 99533-80-9
Empirical Formula (Hill Notation): C27H21N3O5
Molecular Weight: 467.47
EC Number: 200-664-3
MDL Number: MFCD00161522
Linear Formula: C27H21N3O5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-K2015-200UL 200 µL
 $229.00
1/EA		 Add To Favorites

 

assay >98%
biological source Nonomuraea longicatena
form solution
InChI 1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1
InChI key KOZFSFOOLUUIGY-SOLYNIJKSA-N
Quality Level 200 
shipped in dry ice
SMILES string [H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
storage temp. −20°C
Biochem/physiol Actions: K-252a is also a specific inhibitor of Trk (tyrosine kinase) receptors and selectively blocks the effect of nerve growth factor. At lower concentrations, K-252a acts as a neuroprotective compound prompting survival of primary neuronal cultures. K-252a induces cell cycle arrest and apoptosis by inhibiting both Cdc2 and Cdc25c. K-252a improves psoriasis in a SCID mouse-human skin model and also suppresses referred mechanical hypersensitivity and neuropeptide up-regulation associated with acute pancreatitis.
Features and Benefits: This compound is featured on the Met  and PKC  pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Physical form: Supplied as a 0.2 μm-filtered 1 mM solution in dimethyl sulfoxide (DMSO).
RIDADR NA 1993 / PGIII
WGK Germany WGK 1
Flash Point(F) 188.6 °F - closed cup
Flash Point(C) 87 °C - closed cup
Purity >98%
Storage Temp. −20°C
UNSPSC 12352200

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