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K-252a

SIGMA/K1639 - from Nonomuraea longicatena, ≥98% (HPLC)

CAS Number: 99533-80-9
Empirical Formula (Hill Notation): C27H21N3O5
Molecular Weight: 467.47
MDL Number: MFCD00161522
Linear Formula: C27H21N3O5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-K1639-100UG 100 µg
 $231.00
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antibiotic activity spectrum viruses
assay ≥98% (HPLC)
biological source Nonomuraea longicatena
form solid
InChI 1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1
InChI key KOZFSFOOLUUIGY-SOLYNIJKSA-N
mode of action enzyme | inhibits
Quality Level 200 
shipped in dry ice
SMILES string [H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
solubility DMF: 1 mg/mL
  DMSO: 1 mg/mL
storage temp. −20°C
Application: K-252a has been used:
• as a tropomyosin receptor kinase (Trk) inhibitor to study the role of TrkA signaling in rats
• as a Trk inhibitor for inducing in vitro injury in retinal Müller glial cells to study the effects of cord blood serum (CBS)
• as a general protein kinase inhibitor to study its effect on in vitro human somatic testicular cell reassembly
Biochem/physiol Actions: K-252a is a selective inhibitor of tyrosine protein kinase. It targets a wide range of protein kinases with IC50 values between 3 and 25nM and the neurotrophin receptor-tropomyosin receptor kinase.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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