KN-93

SIGMA/K1385 - ≥98% (HPLC)

Synonym: N-[2-[N-(4-Chlorocinnamyl)-N-methylaminomethyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate salt; N-[2-[[[3-(4′-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4′-methoxybenzenesulfonamide phosphate salt

CAS Number: 139298-40-1
Empirical Formula (Hill Notation): C₂₆H₂₉ClN₂O₄S · H₃PO₄
Molecular Weight: 599.03
MDL Number: MFCD03788201
Linear Formula: C₂₆H₂₉ClN₂O₄S · H₃PO₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-K1385-.1MG	0.1 mg	$119.00 1/EA	Add To Favorites
45-K1385-.5MG	0.5 mg	$419.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
biological source	synthetic (organic)
color	white
form	powder
InChI	1S/C26H29ClN2O4S.H3O4P/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25;1-5(2,3)4/h3-16,30H,17-20H2,1-2H3;(H3,1,2,3,4)/b6-5+;
InChI key	NNKJTPOXLIILMB-IPZCTEOASA-N
Quality Level	200
SMILES string	OP(O)(O)=O.COc1ccc(cc1)S(=O)(=O)N(CCO)c2ccccc2CN(C)CC=Cc3ccc(Cl)cc3
solubility	DMSO: 1 mg/mL
	H₂O: soluble
storage temp.	2-8°C

Application:	KN-93 has been used: • as an inhibitor to block αCaMKII (Ca²⁺/calmodulin-dependent protein kinase IIα) • as CaMKII inhibitor to pre-treat hippocampal slices • to treat the cells, to alter the cytoskeleton (CSK) structure and function during the experiment
Biochem/physiol Actions:	KN-93 is a selective Ca²⁺/calmodulin-dependent protein kinase II inhibitor, which has been implicated in the regulation of smooth muscle contractility. CaM kinase II activation was inhibited by KN-93 pretreatment (IC₅₀ ~1 μM). KN-93 inhibited histamine-induced tonic force maintenance, whereas early force development and MLC20 phosphorylation responses during the entire time course were unaffected. Both force development and maintenance in response to KCl were inhibited by KN-93. Rapid increases in KCl-induced MLC20 phosphorylation were also inhibited by KN-93, whereas steady-state MLC20 phosphorylation responses were unaffected. In contrast, phorbol 12,13-dibutyrate (PDBu) did not activate CaM kinase II and PDBu-stimulated force development was unaffected by KN-93. Thus KN-93 appears to target a step(s) essential for force maintenance in response to physiological stimuli, suggesting a role for CaM kinase II in regulating tonic contractile responses in arterial smooth muscle. Pharmacological activation of protein kinase C bypasses the KN-93 sensitive step.
Biochem/physiol Actions:	KN-93 is a selective Ca²⁺/calmodulin-dependent protein kinase II inhibitor.
Disclaimer:	Photosensitive
Features and Benefits:	This compound is featured on the Ca/CaMKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	51111800

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