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Kifunensine

SIGMA/K1140 - mannosidase inhibitor

Synonym: FR 900494; Hexahydro-6R,7S,8aS-trihydroxy-5R-(hydroxymethyl)-imidazo[1,2-a] pyridine-2,3-dione

CAS Number: 109944-15-2
Empirical Formula (Hill Notation): C8H12N2O6
Molecular Weight: 232.19
Linear Formula: C8H12N2O6
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-K1140-1MG 1 mg
 $285.00
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assay ≥98%
biological source synthetic (organic)
form film or powder
  solid
InChI 1S/C8H12N2O6/c11-1-2-3(12)4(13)5(14)6-9-7(15)8(16)10(2)6/h2-6,11-14H,1H2,(H,9,15)/t2-,3-,4+,5+,6+/m1/s1
InChI key OIURYJWYVIAOCW-PQMKYFCFSA-N
Quality Level 100 
SMILES string N21[C@H](NC(=O)C2=O)[C@H]([C@H]([C@@H]([C@H]1CO)O)O)O
solubility water, double-distilled: 50 mM
storage temp. −20°C
Application: Kifunensine has been used as an inhibitor of mannosidase I in Jurkat T-cells, human embryonic kidney (HEK293T/17) cells and in mouse embryonic fibroblast cells.
Biochem/physiol Actions: Kifunensine is a selective inhibitor of class I glycoprotein-processing α-mannosidases.
Biochem/physiol Actions: Kifunensine suppresses endoplasmic reticulum-associated degradation (ERAD) via the inhibition of endoplasmic reticulum-associated mannosidase activity. It is also a glycosidase inhibitor for Class I CAZy glycosylhydrolase family 47.
General description: Kifunensine is an alkaloid compound, isolated from the actinomycete Kitasporia kifunensis.
Purity ≥98%
Storage Temp. −20°C
UNSPSC 12352204

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