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Ketorolac tris salt

SIGMA/K1136 - ≥99%, crystalline

Synonym: (±)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid tris salt; Toradol

CAS Number: 74103-07-4
Empirical Formula (Hill Notation): C15H13NO3 · C4H11NO3
Molecular Weight: 376.40
MDL Number: MFCD00887595
Linear Formula: C15H13NO3 · C4H11NO3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-K1136-1G 1 g
 $188.00
1/EA		 Add To Favorites
45-K1136-5G 5 g
 $736.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: K1136-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: K1136-5G

 

assay ≥99%
biological source synthetic (organic)
form crystalline
InChI 1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2
InChI key BWHLPLXXIDYSNW-UHFFFAOYSA-N
Quality Level 100 
SMILES string NC(CO)(CO)CO.OC(=O)C1CCn2c1ccc2C(=O)c3ccccc3
solubility H2O: soluble 15 mg/mL, clear, colorless to faintly yellow (stable at least one month at −20 °C.)
storage temp. room temp
Application: Ketorolac has been used:
• as an intraperitoneal injection in mice to study the effect of ketorolac on expression of c-Fos (a human proto-oncogene) in ARC (arcuate nucleus of the hypothalamus) POMC (proopiomelanocortin) -EGFP (enhanced green fluorescent protein) neurons
• to treat mice in order to show that this treatment does not prevent IL-1β-mediated inhibition of Agouti-related protein (AgRP) secretion from murine hypothalamic explants
• as an analgesic medication to treat rats induced with acute inflammatory joint injury by injecting carrageenan into the ankle
Biochem/physiol Actions: Ketorolac is a non-steroidal agent that possesses moderate anti-inflammatory activity and is also a potent analgesic. It shows superior analgesic efficacy to that of the opioid analgesics like morphine in patients with moderate to severe postsurgical pain. It inhibits prostaglandin synthesis and platelet aggregation induced by arachidonic acid and collagen. It is a dual COX-1/COX-2 inhibitor.
Disclaimer: Stable at least 2 years if stored at room temperature.
Packaging: 1, 5 g in poly bottle
Purity ≥99%
Storage Temp. room temp
UNSPSC 12352202

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