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JNJ-10198409

SIGMA/J4649 - ≥98% (HPLC), solid

Synonym: 3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine; N-(3-fluorophenyl)-2,4-dihydro-6,7-dimethoxy-Indeno[1,2-c]pyrazol-3-amine; RWJ 540973

CAS Number: 627518-40-5
Empirical Formula (Hill Notation): C18H16FN3O2
Molecular Weight: 325.34
Linear Formula: C18H16FN3O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-J4649-1MG 1 mg
 $225.00
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assay ≥98% (HPLC)
color off-white
form solid
InChI 1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22)
InChI key ZDNURMVOKAERHZ-UHFFFAOYSA-N
originator Johnson & Johnson
Quality Level 100 
SMILES string COc1cc2Cc3c(Nc4cccc(F)c4)n[nH]c3-c2cc1OC
solubility DMSO: >10 mg/mL
  H2O: <2 mg/mL
storage temp. −20°C
Biochem/physiol Actions: JNJ-10198409 is a potent ATP-competitive inhibitor of Platelet-Derived Growth Factor receptor tyrosine kinase (PDGF-RTK) with both antiangiogenic and a direct tumor cell antiproliferative activity. It is selective for PDGF-β kinase with IC50 values of 4.2 nM for PDGF-β and 45 nM for PDGF-α kinase.
Biochem/physiol Actions: JNJ-10198409 is an ATP-competitive Platelet-Derived Growth Factor Receptor-beta (PDGFR-β) inhibitor.
Features and Benefits: This compound is a featured product for Kinase Phosphatase Biology research. Click here  to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the PAF Receptor  and PDGFR  pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by Johnson & Johnson . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 1, 5 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 51111800

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