Monoclonal Anti-Interferon-γ antibody produced in mouse
SIGMA/I5521 - clone 25718, purified immunoglobulin, lyophilized powder
Synonym: Anti-IFN-γ
MDL Number: MFCD00162308
Product Type: Chemical
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| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | 25718, monoclonal |
| conjugate | unconjugated |
| form | lyophilized powder |
| impurities | endotoxin, tested |
| isotype | IgG2a |
| Quality Level | 100  |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunocytochemistry: 8-25 μg/mL using immersion fixed human peripheral blood mononuclear cells stimulated with PMA and ionomycin |
| neutralization: suitable | |
| UniProt accession no. | P01579  |
| Biochem/physiol Actions: | Interferons (IFNs) are cytokines that are secreted in response to viral or bacterial infections and tumorigenesis. IFN-γ binds to specific receptor complex consisting of IFNγR1 and IFNγR2. There are many pathways that are mediated by IFN-γ binding such as JAK/STAT1, AP-1, NF-κB, STAT3 and STAT5. IFN-γ is pleotropic and performs various functions related to immune response, inflammation, differentiation and activation of T cells, cell cycle and apoptosis. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | recombinant human interferon-γ, expressed and purified from Escherichia coli. |
| Physical form: | Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5% trehalose. |
| Preparation Note: | Purified using protein A affinity chromatography. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |