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IRAK-1/4 Inhibitor I

SIGMA/I5409 - ≥98% (HPLC), solid

Synonym: 1-(2-(4-Morpholinyl)ethyl)-2-(3-nitrobenzoylamino)benzimidazole; N-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole

CAS Number: 509093-47-4
Empirical Formula (Hill Notation): C20H21N5O4
Molecular Weight: 395.41
MDL Number: MFCD09752602
Linear Formula: C20H21N5O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-I5409-5MG 5 mg
 $198.00
1/EA		 Add To Favorites
45-I5409-25MG 25 mg
 $776.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color off-white to light yellow
form solid
InChI 1S/C20H21N5O4/c26-19(15-4-3-5-16(14-15)25(27)28)22-20-21-17-6-1-2-7-18(17)24(20)9-8-23-10-12-29-13-11-23/h1-7,14H,8-13H2,(H,21,22,26)
InChI key QTCFYQHZJIIHBS-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C(C1=CC([N+]([O-])=O)=CC=C1)NC2=NC3=C(N2CCN4CCOCC4)C=CC=C3
solubility DMSO: ≥5 mg/mL
storage temp. 2-8°C
Application: IRAK-1/4 inhibitor I has been used in various studies to inhibit IRAK1 in hepatoma cell lines and head and neck squamous cell carcinoma (HNSCC) cell lines.
Biochem/physiol Actions: IRAK-1/4 Inhibitor I is a novel benzimidazole that is a potent inhibitor of interleukin-1 receptor-associated kinases 1/4 (IRAK 1/4). IC50 values were 300 nM and 200 nM for IRAK-1 and -4, respectively, and >10,000 nM for a panel of 27 other kinases tested.
Biochem/physiol Actions: IRAK-1/4 Inhibitor I is a potent inhibitor of interleukin-1 receptor-associated kinases 1/4 (IRAK 1/4, with IC50 values of 300 nM and 200 nM for IRAK-1 and -4, respectively.
Biochem/physiol Actions: IRAK1 overexpression leads to the development of head and neck squamous cell carcinoma (HNSCC). Therefore, IRAK-1/4 inhibitor I might be a potential therapeutic for HNSCC tumors. Various experimental studies states that IRAK-1/4 inhibitor might have a potential to exhibit inhibitory effects on the nuclear factor (NF)-κB signaling pathway.
Packaging: 5, 25 mg in glass bottle
Hazard Codes T
Risk Statements 25-36/37/38
Safety Statements 26-36/37-45
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 3
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51111800

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