Insulin-Like Growth Factor Binding Protein-2 human
SIGMA/I5403 - recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture, ≥95% (SDS-PAGE)
Synonym: IGFBP-2
MDL Number: MFCD02099094
Product Type: Chemical
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| assay | ≥95% (SDS-PAGE) |
| biological source | human |
| form | lyophilized powder |
| impurities | endotoxin, tested |
| mol wt | ~36 kDa by SDS-PAGE |
| calculated mol wt ~31 kDa | |
| packaging | pkg of 25 μg |
| potency | 0.04 μg/mL |
| Quality Level | 100  |
| recombinant | expressed in NSO cells |
| storage condition | avoid repeated freeze/thaw cycles |
| storage temp. | −20°C |
| technique(s) | cell culture | mammalian: suitable |
| UniProt accession no. | P18065  |
| Analysis Note: | The biological activity is measured by its ability to inhibit recombinant human lGF-II on MCF-7 cells. |
| Biochem/physiol Actions: | During development, insulin-like growth factor binding protein-2 is expressed in a number of tissues with the highest expression level found in the central nervous system. IGFBP-2 exhibits a 2-10 fold higher affinity for IGF II than for IGF I. Mouse and human IGFBP-2 share approximately 82% homology. |
| Biochem/physiol Actions: | Exhibits a 2-10 fold higher affinity for IGF II than for IGF I. |
| Biochem/physiol Actions: | IGFBP-2 (insulin-like growth factor binding protein-2) regulates the function of IGF ligands. IGFBP2 is associated with skeletal muscle cell proliferation and differentiation. It also plays an important role in the differentiation of corneal fibroblast. |
| General description: | The gene IGFBP-2 (insulin-like growth factor binding protein-2) is mapped to human chromosome 2q35. |
| Physical form: | Lyophilized from a 0.2 μm filtered solution of 30% (v/v) acetonitrile with 0.1% (v/v) TFA |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H319 - H332 |
| Precautionary statements | P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36 |
| Safety Statements | 26-36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |