Anti-SON antibody produced in rabbit
SIGMA/HPA023535 - Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Synonym: Anti-BASS1; Anti-Bax antagonist selected in saccharomyces 1; Anti-DBP-5; Anti-NRE-binding protein; Anti-Negative regulatory element-binding protein; Anti-SON protein; Anti-SON3
Product Type: Chemical
Immunohistochemistry Immunohistochemical staining of human cerebellum shows moderate to strong positivity in nuclear speckles in Purkinje cells.
Immunohistochemistry Immunohistochemical staining of human tonsil shows moderate to strong positivity in nuclear speckles in germinal center cells.
Immunohistochemistry Immunohistochemical staining of human small intestine shows moderate to strong positivity in nuclear speckles in glandular cells.
Immunohistochemistry Immunohistochemical staining of human prostate shows moderate to strong positivity in nuclear speckles in glandular cells.
Immunofluorescence Immunofluorescent staining of human cell line U-251 MG shows localization to nuclear speckles.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| enhanced validation | independent Learn more about Antibody Enhanced Validation  |
| form | buffered aqueous glycerol solution |
| immunogen sequence | TEVAIESTPMILESSIMSSHVMKGI |
| product line | Prestige Antibodies® Powered by Atlas Antibodies |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunofluorescence: 0.25-2 μg/mL |
| immunohistochemistry: 1:1000-1:2500 | |
| UniProt accession no. | P18583  |
| Application: | Anti-SON antibody produced in rabbit has been used for immunoflorescence. All Prestige Antibodies®Powered by Atlas Antibodies is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information. |
| Application: | Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below. Western Blotting (1 paper) |
| Biochem/physiol Actions: | The gene SON encodes a spliceosome-associated factor that is essential for proper processing of transcripts that are associated with microtubules, centrosome maintenance, and genome stability. It maintains the subnuclear organization of pre-mRNA processing factors in nuclear speckles and targets splicing and transcription in major pathways, such as integrin-mediated cell adhesion, cell cycle regulation, cholesterol biosynthesis, apoptosis and epigenetic regulation of gene expression. The gene is essential of mitotic progression and its loss results in mitotic delay. Deficiency of this protein leads to chromosome congression, compromised chromosome segregation and cytokinesis, which results in cellular aneuploidy and apoptosis. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section. Every Prestige Antibody is tested in the following ways: • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues. • Protein array of 364 human recombinant protein fragments. |
| General description: | The gene SON encodes a DNA binding protein that is mapped to human chromosome 21q22. It encodes a large serine/arginine-rich protein that moves between the nucleus and the cytoplasm based on the phase of the cell cycle. The encoded protein spans a length of 2426 amino acids with domains similar to RNA processing factors. |
| Immunogen: | SON protein recombinant protein epitope signature tag (PrEST) |
| Legal Information: | Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany |
| Other Notes: | Corresponding Antigen APREST73871 |
| Physical form: | Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |