Hydroxyurea
SIGMA/H8627 - 98%, powder
Synonym: Hydroxycarbamide
CAS Number: 127-07-1
Empirical Formula (Hill Notation): CH4N2O2
Molecular Weight: 76.05
EC Number: 204-821-7
MDL Number: MFCD00007943
Linear Formula: NH2CONHOH
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: H8627-100G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: H8627-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: H8627-5G
| assay | 98% |
| color | white |
| form | powder |
| InChI | 1S/CH4N2O2/c2-1(4)3-5/h5H |
| InChI key | VSNHCAURESNICA-UHFFFAOYSA |
| Quality Level | 200  |
| SMILES string | NC(=O)NO |
| solubility | H2O: 50 mg/mL |
| storage temp. | 2-8°C |
| Application: | Hydroxyurea has been used: • for cell cycle synchronization in MCF-7 human breast carcinoma cells, Schizosaccharomyces pombe, primary root of seedling • as a drug for treating the parasite Leishmania mexicana in cell viability and cell cycle assay • as an inhibitor in the cell adhesion and motility assay in Caki control and CD9 knockdown cells |
| Biochem/physiol Actions: | Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. |
| Features and Benefits: | This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| General description: | Hydroxyurea is a hydroxylated analog of urea. It is beneficial in increasing fetal hemoglobin (HbF) levels, which in turn reduces the frequency of severe crises and the need for blood transfusions in sickle cell anemia patients. Hydroxyurea exhibits cell-cycle specificity for the S phase, leading to cell arrest at G1 to S. This non-alkylating S phase-specific myelosuppressive agent has a mechanism of action that is not specific to platelets. |
| Packaging: | 1, 5, 10, 25, 100 g in poly bottle |
| Symbol |  GHS08 |
| Signal word | Danger |
| Hazard statements | H340 - H361 |
| Precautionary statements | P201 - P308 + P313 |
| Hazard Codes | T |
| Risk Statements | 46-63 |
| Safety Statements | 53-36/37-45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | 98% |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |