Dopamine hydrochloride
SIGMA/H8502
Synonym: 2-
CAS Number: 62-31-7
Empirical Formula (Hill Notation): C8H11NO2 · HCl
Molecular Weight: 189.64
EC Number: 200-527-8
MDL Number: MFCD00012898
Linear Formula: (HO)2C6H3CH2CH2NH2·HCl
Product Type: Chemical
| color | , White to Light Yellow to Light Beige |
| form | powder |
| InChI | 1S/C8H11NO2.ClH/c9-4-3-6- |
| InChI key | CTENFNNZBMHDDG-UHFFFAOYSA |
| mp | 248-250 °C (lit.) |
| Quality Level | 200  |
| SMILES string | Cl[H].NCCc1ccc(O)c(O)c1 |
| solubility | alcohol: 20 mg/mL |
| H2O: soluble | |
| storage temp. | 2-8°C |
| Application: | Dopamine hydrochloride has been used:• to study dopamine-mediated transient modulation of the physiological responses in white leg shrimp, Litopenaeus vannamei. • to study dopamine-mediated changes in immunity susceptibility to Lactococcus garvieae in the freshwater giant prawn, Macrobrachium rosenbergii. • to study the molecular link between dopamine-induced oxidative stress and mHtt (mutant Huntingtin) toxicity in relation to the activation of the autophagy pathway in an ‘in vitro’ model of parkinsonian Huntington′s Disease. • as a substrate of the prophenoloxidase (PPO) cascade reaction in the anti-microbial assay targeting methicillin-resistant staphylococcus aureus (MRSA) in the biofilm phase. • added exogenously to the culture medium to study its effect on H. contortus female worms. |
| Disclaimer: | Light sensitive |
| Features and Benefits: | This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| General description: | Dopamine (DA) works as a neurotransmitter in the central nervous system. It is a catecholamine made from the amino acid L-tyrosine. It also works as a hormone in the vesicles of the adrenal medulla, thereby controlling heart beat rate and blood pressure. The Absence of DA-containing neurons is associated with Parkinson’s disease.Dopamine is produced and released by the dopaminergic neurons in the substantia nigra that is in the central nervous system. It is involved in several activities such as movement, behaviour, learning, reward, punishment, dreaming, working, memory, mood, sleep, attention, and inhibition of prolactin production. Dopamine also acts as a precursor in the synthesis of catecholamines like epinephrine and norepinephrine. Increased levels of dopamine via the tuberoinfundibular pathway are associated with Schizophrenia, hallucinations, euphoria, and psychosis. A deficiency of dopamine and norepinephrine indicates the neurochemical basis for attention-deficit hyperactivity disorder (ADHD), a pediatric disorder. |
| Other Notes: | 2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research  |
| Packaging: | 5, 10, 25, 100 g in poly bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301 + P312 + P330 |
| Hazard Codes | Xn,N |
| Risk Statements | 22-50/53 |
| Safety Statements | 61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 248-250 °C (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352116 |