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Herbimycin A from Streptomyces hygroscopicus

SIGMA/H6649 - ≥95% (HPLC), powder

CAS Number: 70563-58-5
Empirical Formula (Hill Notation): C30H42N2O9
Molecular Weight: 574.66
MDL Number: MFCD00151702
Linear Formula: C30H42N2O9
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-H6649-.1MG 0.1 mg
 $349.00
1/EA		 Add To Favorites
45-H6649-1MG 1 mg
 $1180.00
1/EA		 Add To Favorites

 

antibiotic activity spectrum viruses
assay ≥95% (HPLC)
biological source Streptomyces hygroscopicus
color yellow
form powder
InChI 1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(16)35/h9-12,14-15,17,19,23-24,26-28H,13H2,1-8H3,(H2,31,36)(H,32,35)/b11-9-,16-10+,18-12+/t17-,19-,23-,24-,26+,27+,28-/m0/s1
InChI key MCAHMSDENAOJFZ-BVXDHVRPSA-N
mode of action enzyme | inhibits
Quality Level 200 
SMILES string CO[C@H]1C[C@H](C)[C@@H](OC)C2=CC(=O)C=C(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)C(C)=C[C@H](C)[C@H]1OC)C2=O
solubility DMSO: 7.5 mg/mL
storage temp. −20°C
Application: Herbimycin A from Streptomyces hygroscopicus has been used as an inhibitor of Src tyrosine kinase in HEK293T cells and rat intestinal epithelial cells. It has also been used to test its attenuation effect in intimal hyperplasia (IH) post balloon injury in rat carotid artery.
Biochem/physiol Actions: An antibiotic that inhibits protein tyrosine kinase. Herbimycin A is a potent inhibitor of angiogenesis.
Biochem/physiol Actions: Herbimycin A is an inducer of heat shock protein (HSP). It increases HSP expression resulting in the attenuation of ischemia reperfusion induced pulmonary injury.
Disclaimer: Hygroscopic and photosensitive
General description: DMSO stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1.
General description: Herbimycin A from Streptomyces hygroscopicus is a benzoquinoid ansamycin antibiotic. It is an analog of geldanamycin.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Purity ≥95% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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