2,3-Bis(4-hydroxyphenyl)propionitrile

SIGMA/H5915 - ≥98% (HPLC)

Synonym: DPN; Diarylpropionitrile; SC-4473

CAS Number: 1428-67-7
Empirical Formula (Hill Notation): C₁₅H₁₃NO₂
Molecular Weight: 239.27
MDL Number: MFCD01695412
Linear Formula: C₁₅H₁₃NO₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-H5915-5MG	5 mg	$94.80 1/EA		Add To Favorites
45-H5915-25MG	25 mg	$383.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C15H13NO2/c16-10-13(12-3-7-15(18)8-4-12)9-11-1-5-14(17)6-2-11/h1-8,13,17-18H,9H2
InChI key	GHZHWDWADLAOIQ-UHFFFAOYSA-N
Quality Level	100
shipped in	ambient
SMILES string	Oc1ccc(CC(C#N)c2ccc(O)cc2)cc1
solubility	DMSO: 10 mg/mL, clear
sterility	non-sterile
storage condition	desiccated
storage temp.	−20°C

Biochem/physiol Actions:	2,3-Bis(4-hydroxyphenyl)-propionitrile (Diarylprepionitrile, DPN) is an ERβ-selective agonist; IC₅₀ = 15nM. DPN protects WT and ARKO mice and significantly decreases IL-1β following LPS treatment in young adult-derived microglia. PPT (Cat. No.H6036, ERa agonist) enhances cell proliferation, while DPN inhibits it. PPT increases Bcl-2 expression, while DPN decreases it. DPN also elevates Bax expression. DPN induces a dose-dependent increase on vitellogenin synthesis. PPT and DPN are effective in dynamically, but differentially regulating intracellular calcium signaling in hippocampal neurons. DPN is more efficacious than PPT in potentiating a physiological concentration of glutamate-induced intracellular Ca²⁺ rise in these neurons. DPN prevents the development of prostatic hyperplasia and inflammation in testosterone-treated LuRKO mice.
Biochem/physiol Actions:	2,3-Bis(4-hydroxyphenyl)-propionitrile is an ERβ-selective agonist; IC₅₀ = 15nM.
Features and Benefits:	This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07,GHS09
Signal word	Warning
Hazard statements	H319 - H400
Precautionary statements	P273 - P305 + P351 + P338
Hazard Codes	Xi,N
Risk Statements	36-50
Safety Statements	26-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	51111800

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