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(2S,3S)-Hydroxybupropion hydrochloride

SIGMA/H3167 - ≥98% (HPLC)

Synonym: (2S,3S)-Hydroxybupropion hydrochloride; (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol hydrochloride; (2S,3S)-2-(3-Chlorophenyl)-3,5,5-trimethyl-2-morpholinol hydrochloride; GW 353162; Radafaxine hydrochloride; SS-hydroxybupropion hydrochloride

CAS Number: 106083-71-0
Empirical Formula (Hill Notation): C13H18ClNO2 · HCl
Molecular Weight: 292.20
MDL Number: MFCD10565921
Linear Formula: C13H18ClNO2 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-H3167-5MG 5 mg
 $165.00
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45-H3167-25MG 25 mg
 $653.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts H3167-5MG.

 

assay ≥98% (HPLC)
color white to tan
form powder
InChI 1S/C13H18ClNO2.ClH/c1-9-13(16,17-8-12(2,3)15-9)10-5-4-6-11(14)7-10;/h4-7,9,15-16H,8H2,1-3H3;1H/t9-,13+;/m0./s1
InChI key ORXTVTDGPVINDN-BTJVGWIPSA-N
Quality Level 100 
SMILES string Cl.C[C@@H]1NC(C)(C)CO[C@@]1(O)c2cccc(Cl)c2
solubility DMSO: ≥12 mg/mL
storage condition desiccated
storage temp. −20°C
Biochem/physiol Actions: (2S,3S)-hydroxybupropion is a dopamine transporter (DAT) and norepinephrine transporter (NET) transporters inhibitor and nicotinic acetylcholine receptor (nAChR) family modulator. Hydroxybupropions were reported to contribute to antidepressant and perhaps smoking cessation activities. Both (2S,3S) and (2R,3R) metabolites reverse affective and somatic withdrawal signs in nicotine-dependent mice, but (2S,3S)-hydroxybupropion is more potent. (2S,3S)-hydroxybupropion significantly decreases the development of nicotine reward in mice.
Features and Benefits: This compound is featured on the Biogenic Amine Transporters  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description: (2S,3S)-hydroxybupropion is a major metabolite of bupropion.
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H319
Precautionary statements P305 + P351 + P338
Hazard Codes Xi
Risk Statements 36
Safety Statements 26
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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