Hyperforin (dicyclohexylammonium) salt

SIGMA/H1792

Synonym: Hyp-DCHA; Hyperforin-DCHA

CAS Number: 238074-03-8
Empirical Formula (Hill Notation): C₃₅H₅₂O₄·C₁₂H₂₃N
Molecular Weight: 718.10
MDL Number: MFCD04000098
Linear Formula: C₃₅H₅₂O₄·C₁₂H₂₃N
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-H1792-1MG	1 mg	$389.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to off-white
form	powder
InChI	1S/C35H52O4.C12H23N/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10;1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h13-15,18,26-27,38H,12,16-17,19-21H2,1-11H3;11-13H,1-10H2/t27-,33+,34+,35-;/m0./s1
InChI key	ZUYCAROZOLUHJY-DNSWOBEMSA-N
Quality Level	100
SMILES string	C1CCC(CC1)NC2CCCCC2.CC(C)C(=O)[C@@]34C(O)=C(CC=C(C)C)C(=O)[C@@](CC=C(C)C)(C[C@H](CC=C(/C)C)[C@@]3(C)CCC=C(C)C)C4=O
solubility	DMSO: ≥10 mg/mL
storage condition	protect from light
storage temp.	−20°C

Biochem/physiol Actions:	Hyperforin is believed to be the primary active constituent responsible for the antidepressant and anxiolytic properties of the extracts of St. John′s wort.
Biochem/physiol Actions:	Hyperforin is believed to be the primary active constituent responsible for the antidepressant and anxiolytic properties of the extracts of St. John′s wort. It acts as a reuptake inhibitor of monoamines, including serotonin, norepinephrine, dopamine, and of GABA and glutamate by activating the transient receptor potential ion channel TRPC6. It also is an activator of the pregnane X receptor (PXR), which serves as a key regulator of CYP3A4 transcription, a member of the cytochrome (CYP) P450 enzyme system. Recent studies have found it to have neuroprotective effects against Alzheimer′s disease (AD) neuropathology, including the ability to disassemble amyloid-β aggregates in vitro and improve spatial memory in vivo.
Biochem/physiol Actions:	Stable salt of hyperforin.
Biochem/physiol Actions:	Stable salt of hyperforin. Hyperforin is believed to be the primary active constituent responsible for the antidepressant and anxiolytic properties of the extracts of St. John′s wort. It acts as a reuptake inhibitor of monoamines, including serotonin, norepinephrine, dopamine, and of GABA and glutamate by activating the transient receptor potential ion channel TRPC6. Activation of TRPC6 induces the entry of sodium and calcium into the cell which causes inhibition of monoamine reuptake. It also is an activator of the pregnane X receptor (PXR), which serves as a key regulator of CYP3A4 transcription, a member of the cytochrome (CYP) P450 enzyme system. Recent studies have found other neurological effects, effects on inflammation, as well as antibacterial, antitumoral and antiangiogenic effects.
Packaging:	1 mg in glass bottle

Symbol	GHS05,GHS07,GHS09
Signal word	Danger
Hazard statements	H302 - H314 - H400
Precautionary statements	P273 - P280 - P305 + P351 + P338 - P310
Hazard Codes	C,N
Risk Statements	22-34-50/53
Safety Statements	26-36/37/39-45-60-61
RIDADR	UN 1759 8 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

Choose a favorite list for this item:

Catalog Number	Description	Price

		$

Please choose a list :

Continue Shopping

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.