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p-Fluorohexahydro-sila-difenidol hydrochloride

SIGMA/H127 - powder, ≥98% (HPLC)

Synonym: Cyclohexyl-(4-fluorophenyl)-(3-N-piperidinopropyl)silanol hydrochloride; P-F-HHSiD hydrochloride

CAS Number: 116679-83-5
Empirical Formula (Hill Notation): C20H32FNOSi · HCl
Molecular Weight: 386.02
MDL Number: MFCD00078582
Linear Formula: C20H32FNOSi · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-H127-10MG 10 mg
 $313.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C20H32FNOSi.ClH/c21-18-10-12-20(13-11-18)24(23,19-8-3-1-4-9-19)17-7-16-22-14-5-2-6-15-22;/h10-13,19,23H,1-9,14-17H2;1H
InChI key JMTYYLMGSBSPPK-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cl[H].O[Si](CCCN1CCCCC1)(C2CCCCC2)c3ccc(F)cc3
solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >14 mg/mL
  ethanol: soluble
  H2O: slightly soluble 1.5 mg/mL
Application: p-Fluorohexahydro-sila-difenidol hydrochloride (pFHHSid) has been used:
• as the M3/muscarinic acetylcholine receptor antagonist to study its involvement in carbachol induced Egr-1 biosynthesis using human neuroblastoma cells
• as M3 receptor antagonist to test its involvement on N,N-diethyl-m-toluamide (DEET)-induced angiogenesis in human umbilical venous endothelial cells (HUVEC)
• in a study to examine the role of aclidinium on human fibroblast to myofibroblast
Biochem/physiol Actions: High affinity M3 muscarinic acetylcholine receptor antagonist.
Features and Benefits: This compound is featured on the Acetylcholine Receptors (Muscarinic)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 10, 50 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
UNSPSC 12352200

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