[Leu¹⁵]-Gastrin I human

SIGMA/G9145 - ≥95% (HPLC)

Synonym: [Leu¹⁵]-HG-17; LHG-17; [15-Leucine]-Gastrin I, human heptadecapeptide; [18-Pyroglutamic acid, 32-leucine]-Big gastrin I-(18-34)-peptide amide, human; [Leu¹⁵]-Gastrin I, human; [Leu¹⁵]-HG-17; [Leucine¹⁵]-Gastrin I heptadecapeptide; [Leucine¹⁵]-Little gastrin I

CAS Number: 39024-57-2
Empirical Formula (Hill Notation): C₉₈H₁₂₆N₂₀O₃₁
Molecular Weight: 2080.16
EC Number: 254-250-2
MDL Number: MFCD00076502
Linear Formula: C₉₈H₁₂₆N₂₀O₃₁
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-G9145-.1MG	0.1 mg	$117.00 1/EA	Add To Favorites
45-G9145-.5MG	0.5 mg	$388.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95% (HPLC)
biological source	human
form	powder
InChI	1S/C98H126N20O31/c1-49(2)38-68(115-96(147)72(43-55-46-101-60-19-12-10-17-58(55)60)117-98(149)74-20-13-37-118(74)77(122)48-103-86(137)61-25-31-75(120)105-61)93(144)111-66(30-36-82(131)132)92(143)110-65(29-35-81(129)130)91(142)109-64(28-34-80(127)128)90(141)108-63(27-33-79(125)126)89(140)107-62(26-32-78(123)124)88(139)104-51(5)85(136)113-70(41-53-21-23-56(119)24-22-53)87(138)102-47-76(121)106-71(42-54-45-100-59-18-11-9-16-57(54)59)95(146)114-69(39-50(3)4)94(145)116-73(44-83(133)134)97(148)112-67(84(99)135)40-52-14-7-6-8-15-52/h6-12,14-19,21-24,45-46,49-51,61-74,100-101,119H,13,20,25-44,47-48H2,1-5H3,(H2,99,135)(H,102,138)(H,103,137)(H,104,139)(H,105,120)(H,106,121)(H,107,140)(H,108,141)(H,109,142)(H,110,143)(H,111,144)(H,112,148)(H,113,136)(H,114,146)(H,115,147)(H,116,145)(H,117,149)(H,123,124)(H,125,126)(H,127,128)(H,129,130)(H,131,132)(H,133,134)
InChI key	CMVMLPDUAGUTOC-UHFFFAOYSA-N
Quality Level	200
SMILES string	CC(C)CC(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C3CCCN3C(=O)CNC(=O)C4CCC(=O)N4)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(C)C(=O)NC(Cc5ccc(O)cc5)C(=O)NCC(=O)NC(Cc6c[nH]c7ccccc67)C(=O)NC(CC(C)C)C(=O)NC(CC(O)=O)C(=O)NC(Cc8ccccc8)C(N)=O
storage temp.	−20°C
technique(s)	cell culture \| mammalian: suitable
UniProt accession no.	P01350

Amino Acid Sequence:	Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2
Application:	Gastrin has been used: • as a medium supplement establish enteroid cultures • as a supplement to standard Dulbecco′s Modified Eagle Medium (DMEM) culture medium, human minigut medium to establish the growth of crypts.
Biochem/physiol Actions:	Gastrin I analog with full biological activity and improved stability in aqueous solutions. Leu¹⁵ replaces Met¹⁵, that is readily oxidized resulting in loss of biological activity.
General description:	GAST gene encodes for the protein [Leu15]-Gastrin I in human. In human chromosome, the gene GAST is localized on 17q21.2. G cells in the stomach antrum produces the precursor of [Leu15]-Gastrin I, progastrin. Progastrin undergoes cleavage and processing to yield gastrin, which is trophic for the entire gastrointestinal epithelium. Gastrin is essential for the growth of the digestive system and stimulates the production of gastric acid by parietal cells. Gastrin exerts its function through G-protein-coupled receptor called the cholecystokinin (CCK) or CCK-B receptor (CCK-BR). Gastrin release is stimulated by food, especially protein diet and is inhibited by very low pH. Atrophic gastritis, a Helicobacter pylori infection and long-term administration of proton pump inhibitors infection may cause overexpression of gastrin. Gastric adenocarcinoma show high levels of gastrin.
Other Notes:	Lyophilized from 0.1% TFA in H2O

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352209

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