GANT61

SIGMA/G9048 - ≥98% (HPLC)

Synonym: 2,2′-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethyl-benzenamine; NSC 136476

CAS Number: 500579-04-4
Empirical Formula (Hill Notation): C₂₇H₃₅N₅
Molecular Weight: 429.60
MDL Number: MFCD14635408
Linear Formula: C₂₇H₃₅N₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-G9048-5MG	5 mg	$208.00 1/EA	Add To Favorites
45-G9048-25MG	25 mg	$808.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to off-white
form	powder
InChI	1S/C27H35N5/c1-29(2)25-12-7-5-10-23(25)20-31-18-9-19-32(27(31)22-14-16-28-17-15-22)21-24-11-6-8-13-26(24)30(3)4/h5-8,10-17,27H,9,18-21H2,1-4H3
InChI key	KVQOGDQTWWCZFX-UHFFFAOYSA-N
Quality Level	100
SMILES string	N2(C(N(CCC2)Cc4c(cccc4)N(C)C)c3ccncc3)Cc1c(cccc1)N(C)C
solubility	DMSO: >2 mg/mL
storage temp.	2-8°C

Biochem/physiol Actions:	GANT61 blocks hedgehog pathway signaling by inhibiting the transcripional activity of Gli1 (IC50 = 5 μM). GANT 61 led to a regression of 22Rv1 human prostate tumor cell xenografts in nude mice.
Biochem/physiol Actions:	GANT61 is a Hh pathway Gli Inhibitor.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	51111800

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