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G 418 disulfate salt solution

SIGMA/G8168 - 50 mg/mL in H2O, 0.1 μm filtered, BioReagent, suitable for cell culture

Synonym: Antibiotic G418

CAS Number: 108321-42-2
Empirical Formula (Hill Notation): C20H40N4O10 · 2H2SO4
Molecular Weight: 692.71
MDL Number: MFCD00058314
Linear Formula: C20H40N4O10 · 2H2SO4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-G8168-10ML 10 mL
 $118.37
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45-G8168-50ML 50 mL
 $534.00
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45-G8168-100ML 100 mL
 $739.00
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antibiotic activity spectrum parasites
biological source Micromonospora echinospora
color colorless
concentration 50 mg/mL in H2O
form solution
impurities endotoxin, tested
InChI 1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;2*1-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2*(H2,1,2,3,4)/t6?,7-,8+,9+,10+,11-,12-,13-,14+,15+,16-,17-,18+,19-,20+;;/m0../s1
InChI key UHEPSJJJMTWUCP-NKCAIAFTSA-N
mode of action protein synthesis | interferes
mol wt 692.7
packaging pkg of 10 and 100 mL
potency 50-60 mg per mL
product line BioReagent
Quality Level 200 
SMILES string OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](OC[C@@]1(C)O)O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H]([C@H](C)O)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O
solubility H2O: 50 mg/mL, clear
sterility 0.1 μm filtered
storage temp. 2-8°C
technique(s) cell culture | mammalian: suitable
Application: G418 disulfate is an aminoglycoside antibiotic similar in structure to gentamicin used for selection and maintenance of prokaryotic and eukaryotic cells. Optimal concentrations for selection and maintenance vary by cell lines. Bacteria and algae require 5 μg/mL or less while animal cells may require 300-500 μg/mL.
Biochem/physiol Actions: Mode of Action: G418 blocks polypeptide synthesis and protein elongation by inhibiting synthesis at the 70S and 80S ribosomes.

Antimicrobial Spectrum: G418 selects for cells stably transfected with an iNOS promoter construct and neomycin resistance gene and shows activity against protozoa and helminthes.
Disclaimer: The product is stable for two years when stored at 2-8°C.
General description: Chemical structure: aminoglycoside
Storage Temp. 2-8°C
UNSPSC 12352207

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