GW5074

SIGMA/G6416 - powder

Synonym: 3-(3,5-Dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one

CAS Number: 220904-83-6
Empirical Formula (Hill Notation): C₁₅H₈Br₂INO₂
Molecular Weight: 520.94
MDL Number: MFCD03453076
Linear Formula: C₁₅H₈Br₂INO₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-G6416-5MG	5 mg	$193.00 1/EA		Add To Favorites
45-G6416-25MG	25 mg	$715.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	yellow to orange-brown
form	powder
InChI	1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-
InChI key	LMXYVLFTZRPNRV-KMKOMSMNSA-N
Quality Level	100
SMILES string	Oc1c(Br)cc(cc1Br)C=C2/C(=O)Nc3ccc(I)cc23
solubility	DMSO: 5 mg/mL, clear
storage condition	protect from light
storage temp.	room temp

Application:	GW5074 has been used as a specific inhibitor of cRaf1 in C2 murine skeletal myoblasts, HT-29 colorectal adenocarcinoma cell line and neutrophils.
Biochem/physiol Actions:	GW5074 is a cRaf1 kinase inhibitor, which is placed immediately downstream of Ras in the Motogen activated protein kinase (MAPK) signaling pathway. It elicits protection in GW5074 prevents degeneration in Huntington′s disease and also have therapeutic potential in treating neurodegenerative disorders. GW5074 in combination with anti-inflammatory drug, dexamethasone, attenuates sidestream smoke-induced airway inflammation.
Legal Information:	Sold for research purposes under agreement from GlaxoSmithKline
Other Notes:	light sensitive
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	room temp
UNSPSC	12352200

Choose a favorite list for this item:

Catalog Number	Description	Price

		$

Please choose a list :

Continue Shopping

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.