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Geranylgeranyl pyrophosphate ammonium salt

SIGMA/G6025 - solution, ≥95% (TLC), ~1 mg/mL in methanol: NH4OH (7:3)

Synonym: GGPP; all trans-3,7,11,15-Tetramethyl-2,6,10,14-hexadecatetraenyl pyrophosphate ammonium salt

CAS Number: 6699-20-3 (free acid)
Empirical Formula (Hill Notation): C20H36O7P2 · xNH3
Molecular Weight: 450.44 (free acid basis)
MDL Number: MFCD00156114
Linear Formula: C20H36O7P2 · xNH3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-G6025-1VL 1 vial
 $158.00
1/EA		 Add To Favorites
45-G6025-5VL 5 vials
 $537.00
1/EA		 Add To Favorites

 

assay ≥95% (TLC)
concentration ~1 mg/mL in methanol: NH4OH (7:3)
form solution
InChI 1S/C20H36O7P2/c1-17(2)9-6-10-18(3)11-7-12-19(4)13-8-14-20(5)15-16-26-29(24,25)27-28(21,22)23/h9,11,13,15H,6-8,10,12,14,16H2,1-5H3,(H,24,25)(H2,21,22,23)/b18-11+,19-13+,20-15+
InChI key OINNEUNVOZHBOX-QIRCYJPOSA-N
packaging vial of 200 μg
Quality Level 200 
SMILES string CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CCOP(O)(=O)OP(O)(O)=O
storage temp. −20°C
Application: Geranylgeranyl pyrophosphate ammonium salt has been used:
• in the preparation of 2.5X reaction buffer for Rab GGTase assay
• to add to the culture to further drive Hmg2 degradation
• as a substrate to carryout in vitro enzymatic assays for the characterization of the prenyltransferases
• to reverse the action of lovastatin and also used to examine the potential role of GGPP in the study to assess the effects of exposing the melanoma cell lines in the angiogenesis model as a co-culture to lovastatin in vitro
Biochem/physiol Actions: Geranylgeranyl pyrophosphate (GGPP) is a major enzyme that participates in the secondary metabolism of chloroplast. GGPP synthase plays a key role in the biosynthesis of terpenoid. Protein geranylgeranylation, mediated by geranylgeranyl pyrophosphate participates in the development of the ventricular chamber. It also serves as a stage-specific signal to modulate the formation of cardiac cytoarchitecture the time of mid-gestation.
Biochem/physiol Actions: Isoprenoid from the intracellular mevalonate pathway used for prenylation of several low molecular weight G proteins, including Ras. Intermediate in terpene biosynthesis.
Features and Benefits: This compound is a featured product for Cyclic Nucleotide research. Click here  to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 1 vial in serum bottle
Packaging: 5 vials in serum bottle
Purity ≥95% (TLC)
Storage Temp. −20°C
UNSPSC 12352211

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