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Gly-Gly-His

SIGMA/G4541

Synonym: Copper-binding peptide

CAS Number: 7451-76-5
Empirical Formula (Hill Notation): C10H15N5O4
Molecular Weight: 269.26
MDL Number: MFCD03452928; MFCD03452928
Linear Formula: C10H15N5O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-G4541-100MG 100 mg
 $155.00
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45-G4541-500MG 500 mg
 $512.00
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assay ≥98% (TLC)
color white
form solid
InChI 1S/C10H15N5O4/c11-2-8(16)13-4-9(17)15-7(10(18)19)1-6-3-12-5-14-6/h3,5,7H,1-2,4,11H2,(H,12,14)(H,13,16)(H,15,17)(H,18,19)
InChI key PDAWDNVHMUKWJR-UHFFFAOYSA-N
Quality Level 200 
SMILES string [nH]1cnc(c1)CC(NC(=O)CNC(=O)CN)C(=O)O
storage temp. −20°C
Amino Acid Sequence: Gly-Gly-His
Application: Gly-Gly-His has been used:
• as a peptide test probe in the hydrophilic interaction liquid chromatography (HILIC) studies
• in the electrochemical modification of back-side contact transducers (BSC) electrodes in copper (Cu2+) sensing studies
• for the fabrication carbon nanotube electrode for detection of Cu2+ ions
Biochem/physiol Actions: Gly-Gly-His (GGH) tripeptide displays the affinity of copper (Cu2+) complexation. These complexes display good skin tolerance and may be useful in wound healing. GGH copper complexes are proposed to reduce tumor necrosis factor α (TNF-α)-based interleukin 6 (IL-6) secretion by in vivo studies with fibroblasts. GGH is used in comparative studies with other imidazole-containing peptides such as carnosine. An area of active application research involves the GGH binding of copper ions.
General description: Gly-Gly-His (GGH) tripeptide with carboxyl-terminal histidine residue is hydrophilic.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (TLC)
Storage Temp. −20°C
UNSPSC 12352209

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