GW405833 hydrochloride
SIGMA/G1421 - ≥98% (HPLC), solid
Synonym: 1-
CAS Number: 180002-83-9
Empirical Formula (Hill Notation): C23H24Cl2N2O3 · HCl
Molecular Weight: 483.82
MDL Number: MFCD09832650
Linear Formula: C23H24Cl2N2O3 · HCl
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to pink |
| drug control | regulated under CDSA - not available from Sigma-Aldrich Canada |
| form | solid |
| InChI | 1S/C23H24Cl2N2O3.ClH/c1-1 |
| InChI key | JIQYDHDVNNFPMU-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Cl.COc1ccc2n(c(C)c(CCN3CC |
| solubility | DMSO: soluble >10 mg/mL |
| H2O: insoluble <2 mg/mL | |
| storage condition | desiccated |
| storage temp. | 2-8°C |
| Application: | GW405833 hydrochloride has been used as a lysosomal transient receptor potential mucolipin 1 (TRPML1) specific inhibitor to validate if TRPML1 mediates tau release in neurons and also to verify if it mediates the release of lysosomal tau. It has also been used as a TRPML channel blocker to study the effect of mucolipin transient receptor potential cation channel 3 (MCOLN3/TRPML3) function and trafficking on autophagy in HeLa cells. |
| Biochem/physiol Actions: | GW405833 hydrochloride, also known as ML-SI1, is a cell-permeable lysosomal transient receptor potential cation channel, mucolipin subfamily (TRPML) blocker. |
| Biochem/physiol Actions: | GW405833 is a selective cannabanoid CB2 receptor agonist; analgesic. GW405833 binds with high affinity at both human and rat CB2 receptors (Ki′s 3.9 and 3.6 nM); acts as a partial agonist (50% inhibition of forskolin-stimulated cAMP formation compared to full agonist CP55,940). GW405833 has potent analgesic activity in rat models of inflammatory, neuropathic and incisional pain; devoid of CNS effects common with CB1 agonists. |
| Biochem/physiol Actions: | Selective cannabinoid CB2 receptor agonist; analgesic. |
| Features and Benefits: | This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 - H413 |
| Precautionary statements | P273 - P301 + P310 + P330 |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |