Gly-Arg-Gly-Asp-Ser-Pro-Lys

SIGMA/G1269 - ≥97% (HPLC)

Synonym: GRGDSPK

CAS Number: 111119-28-9
Empirical Formula (Hill Notation): C₂₈H₄₉N₁₁O₁₁
Molecular Weight: 715.76
MDL Number: MFCD00076462
Linear Formula: C₂₈H₄₉N₁₁O₁₁
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-G1269-1MG	1 mg	$342.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97% (HPLC)
biological source	human
form	powder
InChI	1S/C28H49N11O11/c29-8-2-1-5-16(27(49)50)37-25(47)19-7-4-10-39(19)26(48)18(14-40)38-24(46)17(11-22(43)44)36-21(42)13-34-23(45)15(35-20(41)12-30)6-3-9-33-28(31)32/h15-19,40H,1-14,29-30H2,(H,34,45)(H,35,41)(H,36,42)(H,37,47)(H,38,46)(H,43,44)(H,49,50)(H4,31,32,33)/t15-,16-,17-,18-,19-/m0/s1
InChI key	ZRVZOBGMZWVJOS-VMXHOPILSA-N
Quality Level	200
SMILES string	NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)CN)C(O)=O
storage temp.	−20°C
technique(s)	blocking: suitable
	ligand binding assay: suitable

Amino Acid Sequence:	Gly-Arg-Gly-Asp-Ser-Pro-Lys
Application:	Gly-Arg-Gly-Asp-Ser-Pro-Lys (RGD peptide) has been used- • as a blocking peptide to inhibit integrin-fibronectin binding • in adhesion assay performed on porcine trophectoderm to study the influence of TGFβ (transforming growth factor) on cell adhesion • for incubation of MC3T3-E1 osteoblast cells to determine its effect on cell adhesion measured by AFM (atomic force microscopy) • for the preparation of RGD.Flt23k.NR nanoparticles • to determine the involvement of RGD-integrin bonding in cell adhesion process
Biochem/physiol Actions:	Fibronectin analog that binds to integrins.
General description:	Gly-Arg-Gly-Asp-Ser-Pro-Lys is a RGD peptide. Naturally occurring RGD peptides, present in the ECM (extracellalar matrix) proteins, are involved in facilitating integrin-mediated cell adhesion to matrix proteins. RGD peptide is present as repeats in cell-adhesion protein, such as fibronectin and vitronectin. This tripeptide is recognized by cells by specific integrins (e.g. β1 , β3 , and β5 subunits), present on the cell surface and associated with the actin filament via the FA (focal adhesion)-complex.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352209

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