DMT-dG(dmf) Phosphoramidite

SIGMA/G115000 - ≥99.0% (reversed phase HPLC)

Synonym: DMT-dG(dmf) Amidite; N-[(dimethylamino)methylene]-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyguanosine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; N2-Dimethylformamidine-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyguanosine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite]

CAS Number: 330628-04-1
Empirical Formula (Hill Notation): C₄₃H₅₃N₈O₇P
Molecular Weight: 824.90
MDL Number: MFCD00797420
Linear Formula: C₄₃H₅₃N₈O₇P
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-G115000-6X5G	5 g	$541.00 1/EA	Add To Favorites
45-G115000-6X10G	10 g	$1070.00 6/EA	Add To Favorites
45-G115000-6X20G	20 g	$1990.00 6/EA	Add To Favorites
45-G115000-100G	100 g	$1560.00 1/EA	Add To Favorites
45-G115000-500G	500 g	$14380.00 1/EA	Add To Favorites
45-G115000-1KG	1 kg	$22270.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

λ	conforms (UV/VIS Identity)
assay	≥99% (³¹P-NMR)
	≥99.0% (reversed phase HPLC)
color	white to off-white
form	powder
InChI	1S/C43H53N8O7P/c1-29(2)51(30(3)4)59(56-24-12-23-44)58-36-25-38(50-28-45-39-40(50)47-42(48-41(39)52)46-27-49(5)6)57-37(36)26-55-43(31-13-10-9-11-14-31,32-15-19-34(53-7)20-16-32)33-17-21-35(54-8)22-18-33/h9-11,13-22,27-30,36-38H,12,24-26H2,1-8H3,(H,47,48,52)/b46-27-/t36-,37+,38+,59?/m0/s1
InChI key	YRQAXTCBMPFGAN-UJASEYITSA-N
mol wt	824.90 g/mol
nucleoside profile	base: deoxyguanosine base protecting group: DMF 2' protecting group: none 5' protecting group: DMT deprotection: fast
product line	Proligo Reagents
Quality Level	200
SMILES string	COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)n3cnc4C(=O)NC(N=C/N(C)C)=Nc34)(c5ccccc5)c6ccc(OC)cc6
storage temp.	-10 to -25°C
technique(s)	oligo synthesis: suitable
type	for DNA synthesis

Features and Benefits:

Key Features of dG(dmf):• dG(dmf) is deprotected faster than the conventional dG(ib): the deprotection time in concentrated ammonia is reduced to 2 hours at 55 °C or 1 hour at 65 °C
• The dG(dmf)-monomer is especially suitable for G-rich sequences: incomplete deprotection is greatly reduced in comparison with the conventional dG(ib)-monomer
• dG(dmf)-phosphoramidite is as stable in solution as the standard dA(bz)-, dC(bz)- and dT-phosphoramidites
• dG(dmf)-phosphoramidite can directly substitute for dG(ib)-phosphoramidite
• No change is required in the reagents commonly used for DNA synthesis (Except a low concentration iodine oxidizer i.e., 0.02 M in iodine, should be employed)

General description:

DMT-dG(dmf) Phosphoramidite belongs to fast deprotection phosphoramidites where the deprotection step of automated oligonucleotide synthesis is integral to synthesis time and final product quality. Changing the dG protecting group to the dimethylformamidine (dmf) baseprotecting group enables the rapid synthesis of high-purity, high-yield oligonucleotide, thus increasing the efficiency of high-throughput production.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥99% (³¹P-NMR); ≥99.0% (reversed phase HPLC)
Storage Temp.	-10 to -25°C
UNSPSC	12352200

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