GR 64349

SIGMA/G113 - >96%

CAS Number: 137593-52-3
Empirical Formula (Hill Notation): C₄₂H₆₈N₁₀O₁₁S
Molecular Weight: 921.11
MDL Number: MFCD00153800
Linear Formula: C₄₂H₆₈N₁₀O₁₁S
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-G113-1MG	1 mg	$941.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	>96%
InChI	1S/C42H68N10O11S/c1-23(2)19-32(40(61)46-27(35(45)56)15-18-64-5)52-17-14-28(42(52)63)47-41(62)34(24(3)4)51-38(59)29(20-25-11-7-6-8-12-25)49-39(60)31(22-53)50-37(58)30(21-33(54)55)48-36(57)26(44)13-9-10-16-43/h6-8,11-12,23-24,26-32,34,53H,9-10,13-22,43-44H2,1-5H3,(H2,45,56)(H,46,61)(H,47,62)(H,48,57)(H,49,60)(H,50,58)(H,51,59)(H,54,55)/t26-,27-,28-,29-,30-,31-,32-,34-/m0/s1
InChI key	HVUNRXRFMQDMBO-NOJSRKIXSA-N
Quality Level	200
SMILES string	CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)CCCCN)C(C)C)C1=O)C(N)=O
storage temp.	−20°C

Amino Acid Sequence:	Lys-Asp-Ser-Phe-Val-Gly-R-γ-lactam-Leu-Met-NH2
Biochem/physiol Actions:	GR 64349 peptide acts as an agonist of neurokinin (NK₂) receptor, which leads to reduced NK₂ response to kainate and AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid), but not to NMDA (N-methyl-D-aspartate).
General description:	Neurokinin (NK) receptors are acted upon by tachykinins or neurokinins namely, NKA and NKB. These are endogenous ligands. An exogenous agonist/ligand for NK₂ is GR 64349 peptide.
Packaging:	1 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	>96%
Storage Temp.	−20°C
UNSPSC	12352202

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