DMT-dG(tac) Phosphoramidite

SIGMA/G112080 - configured for PerkinElmer, configured for Polygen

Synonym: DMT-dG(tac) amidite

CAS Number: 149989-60-6
Empirical Formula (Hill Notation): C₅₂H₆₂N₇O₉P
Molecular Weight: 960.06
MDL Number: MFCD01941141
Linear Formula: C₅₂H₆₂N₇O₉P
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-G112080-12X1G	1 g	$891.00 12/EA		Add To Favorites
45-G112080-12X2G	2 g	$1770.00 12/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

λ	conforms (UV/VIS Identity)
assay	≥98% (³¹P-NMR)
	≥98.0% (reversed phase HPLC)
color	white to light yellow
compatibility	configured for PerkinElmer
	configured for Polygen
form	powder
InChI	1S/C52H62N7O9P/c1-34(2)59(35(3)4)69(66-29-13-28-53)68-43-30-46(58-33-54-47-48(58)56-50(57-49(47)61)55-45(60)32-64-42-26-16-36(17-27-42)51(5,6)7)67-44(43)31-65-52(37-14-11-10-12-15-37,38-18-22-40(62-8)23-19-38)39-20-24-41(63-9)25-21-39/h10-12,14-27,33-35,43-44,46H,13,29-32H2,1-9H3,(H2,55,56,57,60,61)/t43-,44+,46+,69?/m0/s1
InChI key	MCBSUBQIVLOCIW-YEZUPXOUSA-N
mol wt	960.06 g/mol
nucleoside profile	base: deoxyguanosine base protecting group: TAC 2' protecting group: none 5' protecting group: DMT deprotection: fast
product line	Proligo Reagents
Quality Level	200
SMILES string	COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)n3cnc4C(=O)NC(NC(=O)COc5ccc(cc5)C(C)(C)C)=Nc34)(c6ccccc6)c7ccc(OC)cc7
solubility	acetonitrile: 0.2 M, clear
storage temp.	-10 to -25°C
technique(s)	oligo synthesis: suitable
type	for DNA synthesis

General description:	Proligo′s DNA phosphoramidites lead to high-yield and high-quality oligonucleotides due to their high coupling efficiency. The deprotection step of automated oligonucleotide synthesis is integral to synthesis time and final product quality. The high coupling efficiency of Proligo′s DNA phosphoramidites leads to high-yield and high-quality oligonucleotides.Substitution of standard protecting groups with the labile TAC (tert.-butylphenoxyacetyl) protecting group results in ultra-fast and easydeprotection under mild conditions, suitable for oligonucleotides with baselabile monomers and reporters as well as in-situ synthesis schemes on glass surfaces.Key Features of TAC Chemistry• Deprotection of the TAC group is ultra-fast: complete deprotection inconcentrated ammonia occurs within 15 minutes at 55 °C or two hours atroom temperature • Compatible with the AMA deprotection reagent (a mixture of ≥25%ammonia in water with 40% aqueous methylamine I/I, v/v) • Highly soluble in acetonitrile. No need to add co-solvents such asdimethylformamide or methylene chloride • Suitable for the synthesis of oligomers with base-labile units e.g., dyes andmodifiers, because of less exposure to ammonia and the possibility ofroom temperature deprotection • No change is required in the reagents commonly used for DNA synthesis,except that Proligo′s Fast Deprotection Cap A solution is used instead ofCap A solution • The application of dA(tac) minimizes depurination and improves thequality of oligonucleotidesDMT-dG(tac) Phosphoramidite configured for Expedite^™ and PolyGen^® Synthesizers.
Legal Information:	Expedite is a trademark of Applera Corporation or its subsidiaries in the US and/or certain other countries
Legal Information:	PolyGen is a registered trademark of PolyGen GmbH.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (³¹P-NMR); ≥98.0% (reversed phase HPLC)
Storage Temp.	-10 to -25°C
UNSPSC	12352200

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