DMT-dG(ib) Phosphoramidite

SIGMA/G111040 - configured for MerMade

Synonym: DMT-dG(ib) amidite; Guanosine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxy-N-(2-methyl-1-oxopropyl)-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; N-(2-methyl-1-oxopropyl)-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyguanosine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; N2-Isobutyryl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyguanosine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite]

CAS Number: 93183-15-4
Empirical Formula (Hill Notation): C₄₄H₅₄N₇O₈P
Molecular Weight: 839.92
MDL Number: MFCD00055147; MFCD00055147
Linear Formula: C₄₄H₅₄N₇O₈P
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-G111040-6X5G	5 g	$810.00 6/EA	Add To Favorites
45-G111040-6X9.32G	9.32 g	$883.00 1/EA	Add To Favorites
45-G111040-6X10G	10 g	$1110.00 6/EA	Add To Favorites
45-G111040-20X10G	10 g	$3380.00 20/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

λ	conforms (UV/VIS Identity)
assay	≥99% (³¹P-NMR)
	≥99.0% (reversed phase HPLC)
biological source	non-animal source (no BSE/TSE risk)
color	white to off-white
compatibility	configured for MerMade
form	powder or granules
impurities	≤0.3 wt. % water content (Karl Fischer)
InChI	1S/C44H54N7O8P/c1-28(2)41(52)48-43-47-40-39(42(53)49-43)46-27-50(40)38-25-36(59-60(57-24-12-23-45)51(29(3)4)30(5)6)37(58-38)26-56-44(31-13-10-9-11-14-31,32-15-19-34(54-7)20-16-32)33-17-21-35(55-8)22-18-33/h9-11,13-22,27-30,36-38H,12,24-26H2,1-8H3,(H2,47,48,49,52,53)/t36-,37+,38+,60?/m0/s1
InChI key	FDRMKYVTIFSDPR-MMROLVBFSA-N
nucleoside profile	base: deoxyguanosine base protecting group: isobutyryl 2' protecting group: none 5' protecting group: DMT deprotection: standard
product line	Proligo Reagents
Quality Level	200
SMILES string	COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)n3cnc4C(=O)NC(NC(=O)C(C)C)=Nc34)(c5ccccc5)c6ccc(OC)cc6
storage temp.	2-8°C
technique(s)	oligo synthesis: suitable
type	for DNA synthesis

General description:

Proligo′s DNA phosphoramidites lead to high-yield and high-quality oligonucleotides due to their high coupling efficiency. The deprotection step of automated oligonucleotide synthesis is integral to synthesis time and final product quality. Exocyclic amine functions are protected by a benzoyl group (dA(bz) and dC(bz)) or isobutyryl group (dG(ib))Key features of DNA phosphoramidites:• Recommended cleavage and deprotection conditions are 8 hours at 55 °Cor 24 hours at room temperature using concentrated ammonia solution, for standard base-protected oligonucleotides
• The high coupling efficiency of Proligo′s DNA phosphoramidites leads to high-yield and high-quality oligonucleotides
The products belong to MerMade synthesizers.

Packaging:

G111040-1G packaged in a 1 oz bottle with a 28-400 cap
G111040-10G packaged in a 8 oz bottle with a 28-400 cap
G111040-6x5G packaged in a 8 oz bottle with a 28-400 cap
G111040-6x10G packaged in a 8 oz bottle with a 28-400 cap
G111040-20x10G packaged in a 1 L bottle with GL 45

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥99% (³¹P-NMR); ≥99.0% (reversed phase HPLC)
Storage Temp.	2-8°C
UNSPSC	41116107

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