DMT-dG(ib) Pharmadite^®

SIGMA/G11100P

Synonym: DMT-dG(ib) Phosphoramidite; N-(2-methyl-1-oxopropyl)-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyguanosine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

CAS Number: 93183-15-4
Empirical Formula (Hill Notation): C₄₄H₅₄N₇O₈P
Molecular Weight: 839.92
MDL Number: MFCD00055147
Linear Formula: C₄₄H₅₄N₇O₈P
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-G11100P-6X5G	5 g	$1320.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥99.5% (reversed phase HPLC)
	>99.5% (³¹P-NMR)
biological source	non-animal source (no BSE/TSE risk)
color	white to off-white
form	powder or granules
impurities	>= 170ppm, none detected (S/N <2.5)
	≤0.1% single unspecified Imprity (reversed phase HPLC)
	≤0.3% dG2 (reversed phase HPLC, DMT-dG(ib) cyanoethyl-H-posphonate)
	≤0.3% dG3 (reversed phase HPLC, DMT-dG(ib) phosphoramidate)
	≤0.3% P(III) 100-169ppm (³¹P-NMR)
	≤0.30 wt. % water content (Karl Fischer)
	≤0.5% P(V) -25-99ppm (³¹P-NMR)
	≤3.0 wt. % residual solvent content
	≤0.3% dG4 (reversed phase HPLC, DMT-dG(ib)-diisopropylamino-H-phosphonate)
InChI	1S/C44H54N7O8P/c1-28(2)41(52)48-43-47-40-39(42(53)49-43)46-27-50(40)38-25-36(59-60(57-24-12-23-45)51(29(3)4)30(5)6)37(58-38)26-56-44(31-13-10-9-11-14-31,32-15-19-34(54-7)20-16-32)33-17-21-35(55-8)22-18-33/h9-11,13-22,27-30,36-38H,12,24-26H2,1-8H3,(H2,47,48,49,52,53)/t36-,37+,38+,60?/m0/s1
InChI key	FDRMKYVTIFSDPR-MMROLVBFSA-N
nucleoside profile	base: deoxyguanosine base protecting group: isobutyryl 2' protecting group: none 5' protecting group: DMT deprotection: standard
product line	Proligo Reagents
Quality Level	300
SMILES string	COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)n3cnc4C(=O)NC(NC(=O)C(C)C)=Nc34)(c5ccccc5)c6ccc(OC)cc6
solubility	soluble, clear
storage temp.	2-8°C
suitability	conforms to structure for H-NMR
	conforms to structure for LC-MS
technique(s)	oligo synthesis: suitable
type	for DNA synthesis

General description:

DMT-dG(ib) Pharmadite^® is a Pharmadite^® product line that represents a new class of standard protected DNA phosphoramidites designed with highly controlled impurity profiles and exceptional overall purity. Pharmadite phosphoramidites are characterized by their exceptional purity and well-defined impurity profile. In particular, they are essentially free from contaminants that interfere in coupling reactions, such as other nucleosidic or non-nucleosidic phosphoramidites (P(III)-contaminants). All remaining impurities in Pharmadite phosphopramidites, if present, are identified, characterized, and quantified. The impact of any such defined impurities on the synthesis of oligonucleotides is well understood and has been shown to be insignificant.

Legal Information:

Pharmadite is a registered trademark of Merck KGaA, Darmstadt, Germany

RIDADR	NONH for all modes of transport
WGK Germany	WGK 1
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥99.5% (reversed phase HPLC); >99.5% (³¹P-NMR)
Storage Temp.	2-8°C
UNSPSC	41116107

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